粘噻唑
|
|
|
- CAS號(hào):
- 76706-55-3
- 英文名:
- MYXOTHIAZOL
- 英文別名:
- Myxothiazo;MYXOTHIAZOL;5-dimethoxy-4-methyl-;myxothiazolfrommyxobacterium;MYXOTHIAZOL, VIAL WITH 10 MG*;MYXOTHIAZOL FROM MYXOBACTERIUM 95%;MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS;myxothiazol from myxobacterium*myxococcus fulvus;7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide;2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-
- 中文名:
- 粘噻唑
- 中文別名:
- 粘噻唑;黏硫菌素;粘氧噻唑;MYXOTHIAZOLE;化合物 MYXOTHIAZOL
- CBNumber:
- CB0453976
- 分子式:
- C25H33N3O3S2
- 分子量:
- 487.68
- MOL File:
- 76706-55-3.mol
|
|
|
粘噻唑化學(xué)性質(zhì)
-
沸點(diǎn):
-
679.6±65.0 °C(Predicted)
-
|
-
密度:
-
1.158±0.06 g/cm3(Predicted)
-
|
-
儲(chǔ)存條件:
-
-20°C
-
|
-
溶解度:
-
chloroform: soluble9.80 - 10.20mg/mL, clear, colorless to yellow
-
|
-
酸度系數(shù)(pKa):
-
14.07±0.50(Predicted)
-
|
-
形態(tài):
-
Solid
-
|
-
顏色:
-
White to off-white
-
|
-
生物來(lái)源:
-
Myxococcus fulvus Mx f85
-
|
-
InChIKey:
-
XKTFQMCPGMTBMD-ZDBABOMLSA-N
-
|
-
SMILES:
-
CO[C@@H](\C=C\c1csc(n1)-c2csc(n2)[C@@H](C)\C=C\C=C\C(C)C)[C@@H](C)\C(OC)=C\C(N)=O
-
|
粘噻唑性質(zhì)、用途與生產(chǎn)工藝
Myxothiazol 是一種抗真菌抗生素，是線粒體電子傳遞鏈復(fù)合體 Ⅲ (complex III or bc1 complex) 抑制劑。Myxothiazol 在0.01~3 μg/ml 濃度范圍內(nèi)可抑制許多酵母菌和真菌的生長(zhǎng)。
Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml.
Myxothiazol binds to the ubiquinol oxidation site Qo of complex III and blocks electron transfer from ubiquinol to cytochrome b and thus inhibits complex III activity.
Myxothiazol (i.p.; 0.56 mg/kg; daily for 4 days)-induced complex III inhibition can be induced in mice for four days in a row without overt hepatotoxicity or lethality.
|
Animal Model:
|
C57Bl/J6 mice
|
|
Dosage:
|
0.56 mg/kg
|
|
Administration:
|
I.p.; 24 hours intervals for at most 4 times
|
|
Result:
|
A reversible complex III activity decrease to 50% of control value occurred at 2 h post-injection. At 74 h only minor histological changes in the liver were found, supercomplex formation was preserved and no significant changes in the expression of genes indicating hepatotoxicity or inflammation were found.
|
粘噻唑
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2026/06/05 | HY-112177 | 粘噻唑
Myxothiazol | 76706-55-3 | 1 mg | 4200元 |
| 2023/03/20 | HY-112177 | 粘噻唑
Myxothiazol | 76706-55-3 | 5 mg | 10500元 |
76706-55-3, 粘噻唑 相關(guān)搜索:
- Spectrum of Activity
- Peptides
- Mechanism of Action
- Chemical Structure Class
- Cell Stress
- AntifungalAntibiotics
- Antibiotics G-MAntibiotics
- Antibiotics A to
- Antibiotics
- Mitochondrial InhibitorsAntibiotics
- Inhibits an EnzymeNitric Oxide and Cell Stress
- 抑制劑
- BioChemical
- Antibiotics A to Z
- Antibiotics
- Antibiotics G-M
- C25H33N3O3S2
- 粘氧噻唑
- MYXOTHIAZOLE
- 化合物 MYXOTHIAZOL
- 黏硫菌素
- 粘噻唑
- 76706-55-3
- 2,6-Heptadienamide, 7-[2'-[(1S,2E,4E)-1,6-dimethyl-2,4-heptadien-1-yl][2,4'-bithiazol]-4-yl]-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)-
- Myxothiazo
- 2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-
- 2,6-Heptadienamide, 7-(2'-((1S,2E,4E)-1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)-
- myxothiazolfrommyxobacterium
- MYXOTHIAZOL FROM MYXOBACTERIUM 95%
- MYXOTHIAZOL, VIAL WITH 10 MG*
- myxothiazol from myxobacterium*myxococcus fulvus
- 7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide
- 5-dimethoxy-4-methyl-
- MYXOTHIAZOL
- MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS