2,6-二氯嘌呤核苷性質(zhì)、用途與生產(chǎn)工藝

用途

生產(chǎn)方法 

3056-18-6

13276-52-3

在氮氣保護(hù)下，向配備有滴液漏斗的三頸燒瓶中加入450 mL全乙酰基保護(hù)的2,6-二氯嘌呤核苷（0.1摩爾）和無水甲醇，攪拌至體系完全澄清，冷卻至-10℃。緩慢滴加乙酰氯（1.2摩爾），滴加完畢后，繼續(xù)反應(yīng)1.5小時，通過TLC監(jiān)測反應(yīng)進(jìn)度。反應(yīng)完成后，分批向體系中加入固體碳酸鉀直至pH值達(dá)到7-8，過濾反應(yīng)混合物。將濾液濃縮至干，加入適量水，用250 mL乙酸乙酯萃取三次。合并有機(jī)相，用無水硫酸鈉干燥，過濾后濃縮濾液至干。通過加入140 mL異丙醇進(jìn)行結(jié)晶，得到27.3 g 2,6-二氯嘌呤核苷，為白色固體，收率85%。

參考文獻(xiàn)：

[1] Patent: CN105085595, 2017, B. Location in patent: Paragraph 0015; 0016; 0017; 0018

2,6-二氯嘌呤核苷 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

2,6-二氯嘌呤核苷 生產(chǎn)廠家

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