CZ-48
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- CAS號(hào):
- 1374663-29-2
- 英文名:
- CZ-48
- 英文別名:
- CZ-48;SulfoaraFNMN,Sulfo ara F NMN;1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-[[hydroxy(oxido)phosphinothioyl]oxymethyl]oxolan-2-yl]pyridin-1-ium-3-carboxamide;(2S,4aR,6R,7R,7aS)-6-(6-amino-2-chloro-9H-purin-9-yl)-7-hydroxy-2-sulfanyl-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-one
- 中文名:
- CZ-48
- 中文別名:
- 化合物 T13907;化合物 SULFO-ARA-F-NMN;O-(((2R,3R,4S,5R)-5-(3-氨基甲酰基吡啶-1-鎓-1-基)-4-氟-3-羥基四氫呋喃-2-基)甲基)S-硫代氫磷酸酯;PYRIDINIUM, 3-(AMINOCARBONYL)-1-[2-DEOXY-2-FLUORO-5-O-(HYDROXYMERCAPTOPHOSPHINYL)-BETA-D-ARABINOFURANOSYL]-, INNER SALT
- CBNumber:
- CB08054609
- 分子式:
- C11H14FN2O6PS
- 分子量:
- 352.27
- MOL File:
- 1374663-29-2.mol
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CZ-48化學(xué)性質(zhì)
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儲(chǔ)存條件:
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-20°, stored under nitrogen,unstable in solution, ready to use.
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溶解度:
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DMSO: 210 mg/mL (596.12 mM)
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形態(tài):
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Solid
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顏色:
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White to light yellow
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CZ-48性質(zhì)、用途與生產(chǎn)工藝
Sulfo-ara-F-NMN (CZ-48) 是一種煙酰胺單核苷酸 (NMN) 的類(lèi)似物。Sulfo-ara-F-NMN 選擇性激活 SARM1，但抑制 CD38 (IC50 約為 10 μM)。Sulfo-ara-F-NMN 誘導(dǎo)細(xì)胞內(nèi)環(huán)狀 ADP-核糖 (cADPR) 的產(chǎn)生。
Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is an adaptor protein in the Toll-like receptor pathway. Sulfo-ara-F-NMN activates SARM1 to produce cyclic ADP-ribose and induces non-apoptotic cell death.
CZ-48
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-129522 | CZ-48
Sulfo-ara-F-NMN | 1374663-29-2 | 1 mg | 3400元 |
1374663-29-2, CZ-48 相關(guān)搜索:
- 抑制劑
- O-(((2R,3R,4S,5R)-5-(3-氨基甲?；拎?1-鎓-1-基)-4-氟-3-羥基四氫呋喃-2-基)甲基)S-硫代氫磷酸酯
- 化合物 SULFO-ARA-F-NMN
- PYRIDINIUM, 3-(AMINOCARBONYL)-1-[2-DEOXY-2-FLUORO-5-O-(HYDROXYMERCAPTOPHOSPHINYL)-BETA-D-ARABINOFURANOSYL]-, INNER SALT
- 化合物 T13907
- 1374663-29-2
- (2S,4aR,6R,7R,7aS)-6-(6-amino-2-chloro-9H-purin-9-yl)-7-hydroxy-2-sulfanyl-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-2-one
- 1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-[[hydroxy(oxido)phosphinothioyl]oxymethyl]oxolan-2-yl]pyridin-1-ium-3-carboxamide
- SulfoaraFNMN,Sulfo ara F NMN
- CZ-48