環(huán)丙基萘啶羧酸性質(zhì)、用途與生產(chǎn)工藝

用途 

生產(chǎn)方法 

96568-07-9

100361-18-0

以7-氯-1-環(huán)丙基-6-氟-4-氧代-1,4-二氫-1,8-萘啶-3-羧酸乙酯（0.1g，0.32mmol）為原料，將其溶解于THF（5ml）中。向該溶液中加入濃HCl（45μL，0.7mmol）。將反應(yīng)混合物加熱至回流狀態(tài)，持續(xù)反應(yīng)2小時(shí)。通過薄層色譜（TLC）監(jiān)測(cè)反應(yīng)進(jìn)度，確認(rèn)反應(yīng)完成后，將反應(yīng)混合物冷卻至室溫。過濾收集析出的固體，得到目標(biāo)產(chǎn)物7-氯-1-環(huán)丙基-6-氟-1,4-二氫-4-氧代-1,8-萘啶-3-羧酸，產(chǎn)量為70mg，收率為78%。

參考文獻(xiàn)：

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 7, p. 2428 - 2433

[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 25, p. 5564 - 5575

[3] Patent: WO2005/40164, 2005, A1. Location in patent: Page/Page column 10-12

環(huán)丙基萘啶羧酸 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

環(huán)丙基萘啶羧酸 生產(chǎn)廠家

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