ZONIPORIDE DIHYDROCHLORIDE
|
|
|
- CAS號(hào):
- 241800-97-5
- 英文名:
- ZONIPORIDE DIHYDROCHLORIDE
- 英文別名:
- Zoniporide dihydroch;ZONIPORIDE DIHYDROCHLORIDE;[1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine hydrochloride;[1-(QUINOLIN-5-YL)-5-CYCLOPROPYL-1H-PYRAZOLE-4-CARBONYL]GUANIDINE DIHYDROCHLORIDE;5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide:hydrochloride
- 中文名:
- ZONIPORIDE DIHYDROCHLORIDE
- 中文別名:
- 化合物ZONIPORIDE;N-氨基甲酰亞胺基-5-環(huán)丙基-1-(喹啉-5-基)-1h-吡唑-4-甲酰胺鹽酸鹽
- CBNumber:
- CB12453438
- 分子式:
- C17H17ClN6O
- 分子量:
- 356.81
- MOL File:
- 241800-97-5.mol
|
|
|
ZONIPORIDE DIHYDROCHLORIDE化學(xué)性質(zhì)
-
儲(chǔ)存條件:
-
Desiccate at -20°C
-
|
-
溶解度:
-
≤1mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
-
|
-
形態(tài):
-
crystalline solid
-
|
-
穩(wěn)定性:
-
Hygroscopic
-
|
ZONIPORIDE DIHYDROCHLORIDE性質(zhì)、用途與生產(chǎn)工藝
Zoniporide (CP-597396) hydrochloride 是 1 型鈉氫交換劑 (NHE-1) 的有效和選擇性抑制劑。Zoniporide hydrochloride 抑制人 NHE-1 (IC50=14 nM)，與其他 NHE 亞型相比具有大于 150 倍的選擇性，并有效抑制離體 NHE-1 依賴性的人血小板溶脹 (IC50=59 nM)。
Zoniporide (0.25-4 mg/kg; i.v.; every hour for 2 hours) elicits a dose-dependent reduction in infarct size (ED
50
=0.45 mg/kg/h) in open chest anesthetized rabbits.
Zoniporide exhibits moderate plasma protein binding, has a t
1/2
of 1.5 hours in monkeys, and has one major active metabolite.
Zoniporide treatment shows the AUC
0-∞
and t
1/2
are 0.07 μg h/mL and 0.5 hours, respectively.
|
Animal Model:
|
Rabbit
|
|
Dosage:
|
0.25, 1, 4 mg/kg
|
|
Administration:
|
Every hour for 2 hours; intravenous injection
|
|
Result:
|
Elicited a significant dose-dependent reduction in infarct size in the anesthetized rabbit. The ED
50
was 0.45 mg/kg/h.
|
|
Animal Model:
|
Rat
|
|
Dosage:
|
1 mg/kg
|
|
Administration:
|
Intravenous injection(Pharmacokinetic Analysis)
|
|
Result:
|
The AUC
0-∞
and t
1/2
were 0.07 μg h/mL and 0.5 hours, respectively.
|
ZONIPORIDE DIHYDROCHLORIDE
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
ZONIPORIDE DIHYDROCHLORIDE
生產(chǎn)廠家
ZONIPORIDE DIHYDROCHLORIDE 圖譜信息:
241800-97-5, ZONIPORIDE DIHYDROCHLORIDE 相關(guān)搜索:
- 抑制劑
- C17H16N6OClH
- C17H16N6OHCl
- C17H16N6O2HCl
- N-氨基甲酰亞胺基-5-環(huán)丙基-1-(喹啉-5-基)-1h-吡唑-4-甲酰胺鹽酸鹽
- 化合物ZONIPORIDE
- 241800-97-5
- Zoniporide dihydroch
- 5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide:hydrochloride
- [1-(quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine hydrochloride
- ZONIPORIDE DIHYDROCHLORIDE
- [1-(QUINOLIN-5-YL)-5-CYCLOPROPYL-1H-PYRAZOLE-4-CARBONYL]GUANIDINE DIHYDROCHLORIDE