2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-
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- CAS號(hào):
- 1373765-19-5
- 英文名:
- 2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-
- 英文別名:
- IPSU;IPSU, 10 mM in DMSO;2-(1H-Indol-3-ylmethyl)-9-(4-methoxy-2-pyrimidinyl)-2,9-diazaspiro[5.5]undecan-1-one;inhibit,HCRT Receptor,Hypocretin Receptor,IPSU,Orexin Receptor (OX Receptor),Inhibitor;2-((1H-indol-3-yl)methyl)-9-(4-methoxypyrimidin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one;2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-
- 中文名:
- 2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-
- 中文別名:
- IPSU試劑;IPSU試劑;化合物IPSU;化合物IPSU,10 MM DMSO 溶液
- CBNumber:
- CB12667396
- 分子式:
- C23H27N5O2
- 分子量:
- 405.49
- MOL File:
- 1373765-19-5.mol
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2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-化學(xué)性質(zhì)
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沸點(diǎn):
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702.0±70.0 °C(Predicted)
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密度:
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1.32±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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DMSO:30.0(Max Conc. mg/mL);73.98(Max Conc. mM)
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形態(tài):
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A crystalline solid
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酸度系數(shù)(pKa):
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16.94±0.30(Predicted)
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顏色:
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White to off-white
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2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-性質(zhì)、用途與生產(chǎn)工藝
IPSU是一種選擇性，有口服活性和腦滲透性的OX2R拮抗劑，pKi值為7.85。
pKi: 7.85 (OX2R), 6.29 (OX1R)
Orexin receptor antagonists represent attractive targets for the development of drugs for the treatment of insomnia. IPSU binds rapidly and reaches equilibrium very quickly in binding and/or functional assays.
IPSU has low blood clearance, shows high maximal blood exposure and AUC after oral dosing. It exhibits an acceptable absolute oral bioavailability and a brain/blood concentration ratio that indicated favorable brain penetration. IPSU increases sleep when dosed during the mouse active phase (lights off); IPSU induces sleep primarily by increasing NREM sleep. IPSU shows a fast onset of action, with a clear increase in total sleep time during the first hour afterdosing. The effect lasts 4-5 h, after which time the total sleep time per hour is the same as on vehicle day .
2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-13796 | IPSU | 1373765-19-5 | 1 mg | 240元 |
| 2026/06/05 | HY-13796 | 2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-
IPSU | 1373765-19-5 | 5mg | 640元 |
2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-
生產(chǎn)廠家
2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)- 圖譜信息:
1373765-19-5, 2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)- 相關(guān)搜索:
- 抑制劑
- IPSU試劑
- IPSU試劑
- 化合物IPSU,10 MM DMSO 溶液
- 化合物IPSU
- 1373765-19-5
- IPSU, 10 mM in DMSO
- inhibit,HCRT Receptor,Hypocretin Receptor,IPSU,Orexin Receptor (OX Receptor),Inhibitor
- 2-((1H-indol-3-yl)methyl)-9-(4-methoxypyrimidin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one
- 2-(1H-Indol-3-ylmethyl)-9-(4-methoxy-2-pyrimidinyl)-2,9-diazaspiro[5.5]undecan-1-one
- IPSU
- 2,9-Diazaspiro[5.5]undecan-1-one, 2-(1H-indol-3-ylMethyl)-9-(4-Methoxy-2-pyriMidinyl)-