ML188
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- CAS號(hào):
- 1417700-13-0
- 英文名:
- ML188
- 英文別名:
- ML188;ML188 ，S0793;ML188, 10 mM in DMSO;(R)-N-(4-(tert-Butyl)phenyl)-N-(2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl)furan-2-carboxamide;3-Pyridineacetamide, N-(1,1-dimethylethyl)-α-[[4-(1,1-dimethylethyl)phenyl](2-furanylcarbonyl)amino]-, (αR)-;Inhibitor,SARS coronavirus,infection,non-covalent,ML-188,ML 188,ML188,antiviral,SARS-CoV,Virus Protease,probe,inhibit,replication
- 中文名:
- ML188
- 中文別名:
- 化合物ML188;ML188 ,S0793;化合物ML188,10 MM DMSO 溶液;(R)-N-(4-(叔丁基)苯基)-N-(2-(叔丁基氨基)-2-氧代-1-(吡啶-3-基)乙基)呋喃-2-甲酰胺
- CBNumber:
- CB15867652
- 分子式:
- C26H31N3O3
- 分子量:
- 433.55
- MOL File:
- 1417700-13-0.mol
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ML188化學(xué)性質(zhì)
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沸點(diǎn):
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630.7±55.0 °C(Predicted)
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密度:
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1.142±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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2-8°C
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溶解度:
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DMSO: 250 mg/mL (576.65 mM)
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酸度系數(shù)(pKa):
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14.24±0.46(Predicted)
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形態(tài):
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Solid
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顏色:
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White to Off-White
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ML188性質(zhì)、用途與生產(chǎn)工藝
ML188，一種探針，也是一種選擇性非共價(jià) SARS-CoV 3CLpro 抑制劑， IC50 為 1.5 μM。具有抗病毒活性。
ML188 (0-30 μM; 48 hours) effectively inhibit SARS-CoV replication in cell culture.
Probe ML188 is a modest molecular weight SARS-CoV 3CLpro inhibitor with demonstrated antiviral activity and a non-covalent mechanism of action. ML188 yields an antiviral EC
50
value ranging from 12.9 to 13.4 μM in mock-infected and SARS-CoV infected cells.
Cell Viability Assay
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Cell Line:
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Vero E6 cells (mock-infected or infected with SARS-CoV)
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Concentration:
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3, 4, 5, 8,10, 15, 20, 30 μM
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Incubation Time:
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48 hour
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Result:
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Against mock-infected and SARS-CoV infected cells.
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ML188
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2026/06/05 | HY-136259 | ML188 | 1417700-13-0 | 1 mg | 1000元 |
| 2026/06/05 | HY-136259 | ML188
ML188 | 1417700-13-0 | 5mg | 2700元 |
1417700-13-0, ML188 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- ML188 ,S0793
- 化合物ML188,10 MM DMSO 溶液
- 化合物ML188
- (R)-N-(4-(叔丁基)苯基)-N-(2-(叔丁基氨基)-2-氧代-1-(吡啶-3-基)乙基)呋喃-2-甲酰胺
- 1417700-13-0
- ML188 ，S0793
- ML188, 10 mM in DMSO
- Inhibitor,SARS coronavirus,infection,non-covalent,ML-188,ML 188,ML188,antiviral,SARS-CoV,Virus Protease,probe,inhibit,replication
- (R)-N-(4-(tert-Butyl)phenyl)-N-(2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl)furan-2-carboxamide
- 3-Pyridineacetamide, N-(1,1-dimethylethyl)-α-[[4-(1,1-dimethylethyl)phenyl](2-furanylcarbonyl)amino]-, (αR)-
- ML188