1-Cbz-4-羥甲基哌啶性質(zhì)、用途與生產(chǎn)工藝

用途

生產(chǎn)方法 

6457-49-4

501-53-1

122860-33-7

以4-羥甲基哌啶和氯甲酸芐酯為原料合成N-CBZ-4-哌啶甲醇(1-CBZ-4-羥甲基哌啶)的一般步驟：在無水二氯甲烷(DCM, 100 mL)中溶解4-羥甲基哌啶(2.0 g, 17.4 mmol)，將溶液冷卻至0℃并攪拌。依次加入三乙胺(4.8 mL, 34.8 mmol)和氯甲酸芐酯(3.7 mL, 34.8 mmol)，然后將反應(yīng)混合物緩慢升溫至室溫并繼續(xù)攪拌2小時(shí)。反應(yīng)完成后，將混合物轉(zhuǎn)移至分液漏斗中，加入DCM(50 mL)和水(30 mL)進(jìn)行分層。分離有機(jī)相，水相用DCM(2×50 mL)萃取。合并所有有機(jī)相，用鹽水(30 mL)洗滌一次，經(jīng)無水硫酸鈉干燥后，減壓濃縮得到粗產(chǎn)物。粗產(chǎn)物通過柱色譜法純化，使用己烷/EtOAc(70%至100%)梯度洗脫，得到3.85 g(89%產(chǎn)率)的N-芐氧基羰基-4-(羥甲基)哌啶(E-12)，為透明油狀物。其1H NMR(CDCl3)數(shù)據(jù)如下：δ 1.17(m, 2H), 1.72(m, 3H), 2.15(br s, 1H), 2.78(t, 2H, J = 12 Hz), 3.47(d, 2H, J = 6.04 Hz), 4.20(d, 2H, J = 11.68 Hz), 5.12(s, 2H), 7.33(m, 5H)。

參考文獻(xiàn)：

[1] Patent: WO2005/80394, 2005, A1. Location in patent: Page/Page column 131

[2] European Journal of Organic Chemistry, 2008, # 25, p. 4277 - 4295

[3] Patent: WO2010/46780, 2010, A2. Location in patent: Page/Page column 63-64

[4] Journal of the American Chemical Society, 2017, vol. 139, # 24, p. 8110 - 8113

[5] Patent: US2003/55244, 2003, A1

1-Cbz-4-羥甲基哌啶 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

1-Cbz-4-羥甲基哌啶 生產(chǎn)廠家

1-Cbz-4-羥甲基哌啶 圖譜信息:

122860-33-7, 1-Cbz-4-羥甲基哌啶 相關(guān)搜索:

• Amines and Anilines
• Alcohols and Derivatives
• Piperidine
• pharmacetical
• 化工原料及中間體
• 高端化學(xué)
• 哌啶
• 哌啶系列
• 醫(yī)藥中間體
• 氮雜環(huán)
• 醇類及衍生物
• 胺類和苯胺類
• ALCOHOL
• 112860-33-7
• 4-(羥甲基)哌啶-1-甲酸芐酯
• N- CBZ-4-PIPERIDINEMETHANOL ?????????N-CBZ-4-哌啶甲醇
• N-CBZ-4-哌啶甲醇N-CBZ-4-哌啶甲醇
• 苯甲基 4-(羥甲基)哌啶-1-甲酸基酯
• N-CBZ-4-哌啶甲醇98%
• 1-CBZ-4-羥甲基哌啶(CAS號(hào):122860-33-7)
• N-CBZ-4-哌啶甲醇(1-CBZ-4-羥甲基哌啶)
• N-CBZ-4-哌啶甲醇
• 1-CBZ-4-哌啶甲醇
• 1-CBZ-4-哌啶甲醇 30G左右,94%
• N-CBZ-4-哌啶甲醇或1-CBZ-4-羥甲基哌啶
• N-CBZ-4-哌啶甲醇 98% 25G
• N-CBZ-4-哌啶甲
• 1-CBZ-4-羥甲基哌啶
• N-芐氧羰基-4-哌啶甲醇
• N-CBZ-4-羥甲基哌啶
• 122860-33-7
• BENZYL 4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE
• benzyl 4-(hydroxymethyl)piperidine-N-carboxylate
• Benzyl 4-(hydroxymethyl)piperidin-1-carboxylate
• 1-Cbz-4-hydroxymethylpiperidine - [H12353]
• N- Cbz-4-piperidinemethanol
• 4-(hydroxymethyl)-1-Piperidinecarboxylic acid phenylmethyl ester (9CI ACI)
• 1-Piperidinecarboxylic acid, 4-(hydroxymethyl)-, phenylmethyl ester (9CI, ACI)
• N-Cbz-4-(hydroxymethyL
• N-Cbz-4-PiperidineMethanolor benzyl-4-(hydroxyMethyl)tetrahydro-1(2h)-pyridinecarboxylate
• Phenylmethyl 4-(hydroxymethyl)-1-piperidinecarboxylate
• 1-Piperidinecarboxylic acid, 4-(hydroxymethyl)-, phenylmethyl ester (9CI)
• 1-Piperidinecarboxylic acid, 4-(hydroxyMethyl)-, phenylMethyl ester
• N-(Benzyloxycarbonyl)-4-(Hydroxymethyl)piperidine, 97 %
• N-Cbz-4-(hydroxymethyl)piperidine
• 1-N-Cbz-4-Hydroxymethyl-piperidine
• BENZYL 4-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
• BUTTPARK 75\50-51
• Z-PIC(4)-OL
• Z-ISONIPECOTINOL
• Z-ISONICOT(H6)-OL
• N-(BENZYLOXYCARBONYL)-4-(HYDROXYMETHYL)PIPERIDINE
• N-CARBOBENZOXY-HEXAHYDROISONICOTINOL
• N-CARBOBENZOXY-4-PIPERIDINEMETHANOL
• N-CARBOBENZOXY-4-PIPECOLINOL
• 4-HYDROXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
• 1-N-CBZ-HYDROXYMETHYL-PIPERIDINE
• 1-CBZ-4-HYDROXYMETHYLPIPERIDINE