EPSILON-AMANITIN
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- CAS號:
- 21705-02-2
- 英文名:
- EPSILON-AMANITIN
- 英文別名:
- EPSILON-AMANITIN;α-Amanitin, 1-L-aspartic acid-3-[(4S)-4-hydroxy-L-isoleucine]-;Cyclo[L-Asp-L-t4Hyp-[(4S)-4-hydroxy-L-Ile-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-]
- 中文名:
- 中文別名:
- CBNumber:
- CB21423789
- 分子式:
- C39H53N9O14S
- 分子量:
- 903.96
- MOL File:
- 21705-02-2.mol
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EPSILON-AMANITIN化學(xué)性質(zhì)
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密度:
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1.1627 (rough estimate)
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折射率:
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1.7400 (estimate)
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EPSILON-AMANITIN性質(zhì)、用途與生產(chǎn)工藝
ε-Amanitin，從多種蘑菇中分離出的環(huán)狀肽，可有效與 RNA 聚合酶 II (RNA polymerase II) 結(jié)合并抑制其活性。
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Traditional Cytotoxic Agents
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Amatoxin Family includes alpha-Amanitin, beta-Amanitin, gamma-Amanitin, epsilon-Amanitin (ε-Amanitin), Amanullin, Amanullinic acid, Amaninamide, Amanin and Proamanullin. Amatoxins are potent and selective inhibitors of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). By inhibiting the synthesis of mRNA, Amatoxins thereby stop cell metabolism by inhibiting transcription and protein biosynthesis, which results in cellular apoptosis. Consequently Amatoxins stop cell growth and proliferation.
類別
有毒物品
毒性分級
劇毒
急性毒性
腹腔-小鼠LD50:0.3 毫克/公斤; 未名-小鼠 LD50: 0.5 毫克/公斤
可燃性危險特性
可燃;燃燒產(chǎn)生有毒氮氧化物和硫氧化物煙霧
儲運(yùn)特性
庫房通風(fēng)低溫干燥
滅火劑
干粉、泡沫、砂土、二氧化碳, 霧狀水
EPSILON-AMANITIN
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
EPSILON-AMANITIN
生產(chǎn)廠家
21705-02-2, EPSILON-AMANITIN 相關(guān)搜索:
- C39H53N9O14S
- 21705-02-2
- α-Amanitin, 1-L-aspartic acid-3-[(4S)-4-hydroxy-L-isoleucine]-
- Cyclo[L-Asp-L-t4Hyp-[(4S)-4-hydroxy-L-Ile-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-]
- EPSILON-AMANITIN