2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid
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- CAS號(hào):
- 853929-59-6
- 英文名:
- 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid
- 英文別名:
- OGT 2115;OGT 2115, 10 mM in DMSO;(E)-2-(2-(4-(3-(4-Bromophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acid;2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid;2-2-4-1-(4-Bromophenyl)-3-oxoprop-1-en-2-ylamino-3-fluorophenyl-1,3-benzoxazol-5-ylaceticacid;5-Benzoxazoleacetic acid, 2-[4-[[3-(4-bromophenyl)-1-oxo-2-propen-1-yl]amino]-3-fluorophenyl]-;2-(2-(4-(3-(4-Bromophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acid , OGT 2115
- 中文名:
- 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid
- 中文別名:
- 化合物 T16380;化合物 OGT 2115;OGT 2115,乙酰肝素酶抑制劑;化合物OGT 2115,10 MM DMSO 溶液;化合物：OGT 2115 CAS:853929-59-6;化合物:OGT 2115 CAS:853929-59-6;2-(2-(4-(3-(4-溴苯基)丙烯酰胺基)-3-氟苯基)苯并[D]惡唑-5-基)乙酸;2-[4-[[3-(4-溴苯基)-1-氧代-2-丙烯基]氨基] -3-氟苯基] -5-苯并惡唑乙酸
- CBNumber:
- CB22518952
- 分子式:
- C24H16BrFN2O4
- 分子量:
- 495.3
- MOL File:
- 853929-59-6.mol
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2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid化學(xué)性質(zhì)
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沸點(diǎn):
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685.9±55.0 °C(Predicted)
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密度:
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1.574±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at RT
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溶解度:
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Soluble to 10 mM in DMSO
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形態(tài):
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Powder
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酸度系數(shù)(pKa):
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3.85±0.30(Predicted)
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顏色:
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White to yellow
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InChI:
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InChI=1S/C24H16BrFN2O4/c25-17-6-1-14(2-7-17)4-10-22(29)27-19-8-5-16(13-18(19)26)24-28-20-11-15(12-23(30)31)3-9-21(20)32-24/h1-11,13H,12H2,(H,27,29)(H,30,31)
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InChIKey:
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LKBXWNYXDMSFQU-UHFFFAOYSA-N
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SMILES:
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O1C2=CC=C(CC(O)=O)C=C2N=C1C1=CC=C(NC(=O)C=CC2=CC=C(Br)C=C2)C(F)=C1
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2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid性質(zhì)、用途與生產(chǎn)工藝
OGT 2115 是一種有效的，細(xì)胞可滲透且口服活性的乙酰肝素酶 (heparanase) 抑制劑，IC50 為 0.4 μM。OGT 2115 具有抗血管生成特性 (IC50 為 1 μM)。OGT 2115 還抑制硫酸乙酰肝素的降解活性。
IC50: 0.4 μM (Heparanase)
Heparanase InhibitorOGT 2115 can suppress metastasis induced by endoplasmic reticulum (ER) stress in breast cancer cells, although not significantly. However, compared with the control group, the number and rate of migrated cells are significantly reduced following the exposure of the cells to Tunicamycin + OGT 2115. OGT 2115 significantly inhibits the invasion and migration induced by Adriamycin. Furthermore, the MTT assay results show that OGT 2115 does not decrease the anti-proliferative effect of Adriamycin.
When administered to mice, OGT 2115 (Compound 12d) shows a plasma concentration of ~10x the heparanase IC
50
following oral dosing at 20 mg/kg.
2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-100898 | 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid
OGT 2115 | 853929-59-6 | 5mg | 800元 |
| 2026/06/05 | HY-100898 | 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid
OGT 2115 | 853929-59-6 | 10 mM * 1 mLin DMSO | 872元 |
2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid
生產(chǎn)廠家
2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid 圖譜信息:
853929-59-6, 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- C24H16BrFN2O4
- 2-[4-[[3-(4-溴苯基)-1-氧代-2-丙烯基]氨基] -3-氟苯基] -5-苯并惡唑乙酸
- 化合物：OGT 2115 CAS:853929-59-6
- 化合物:OGT 2115 CAS:853929-59-6
- 化合物OGT 2115,10 MM DMSO 溶液
- 2-(2-(4-(3-(4-溴苯基)丙烯酰胺基)-3-氟苯基)苯并[D]惡唑-5-基)乙酸
- 化合物 OGT 2115
- OGT 2115,乙酰肝素酶抑制劑
- 化合物 T16380
- 853929-59-6
- OGT 2115, 10 mM in DMSO
- 2-(2-(4-(3-(4-Bromophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acid , OGT 2115
- 2-2-4-1-(4-Bromophenyl)-3-oxoprop-1-en-2-ylamino-3-fluorophenyl-1,3-benzoxazol-5-ylaceticacid
- 5-Benzoxazoleacetic acid, 2-[4-[[3-(4-bromophenyl)-1-oxo-2-propen-1-yl]amino]-3-fluorophenyl]-
- (E)-2-(2-(4-(3-(4-Bromophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acid
- OGT 2115
- 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid