AF-DX-384; AF-DX384
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- CAS號(hào):
- 118290-26-9
- 英文名:
- N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
- 英文別名:
- AF-DX-384; AF-DX384;AF-DX 384 Free Base;N-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide;N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide;11H-Pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide, N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-
- 中文名:
- AF-DX-384; AF-DX384
- 中文別名:
- 化合物 T22555;化合物 AF-DX 384;N-[2-[2-[(二丙基氨基)甲基]-1-哌啶基]乙基]-5,6-二氫-6-氧代-11H-吡啶并[2,3-B][1,4]苯并二氮雜卓-1-甲酰胺
- CBNumber:
- CB22751069
- 分子式:
- C27H38N6O2
- 分子量:
- 478.63
- MOL File:
- 118290-26-9.mol
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AF-DX-384; AF-DX384化學(xué)性質(zhì)
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沸點(diǎn):
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618.4±55.0 °C(Predicted)
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密度:
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1.144±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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room temp
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溶解度:
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DMSO: soluble10mg/mL, clear (warmed)
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酸度系數(shù)(pKa):
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11.55±0.20(Predicted)
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形態(tài):
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powder
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顏色:
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white to beige
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InChIKey:
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MZDYABXXPZNUCT-UHFFFAOYSA-N
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SMILES:
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N4(C(CCCC4)CN(CCC)CCC)CCNC(=O)[n]1c2ncccc2[nH][c](c3c1cccc3)=O
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AF-DX-384; AF-DX384性質(zhì)、用途與生產(chǎn)工藝
AF-DX 384 是 M2 和 M4 毒蕈堿乙酰膽堿受體的選擇性拮抗劑 ，Ki 分別為 6.03 nM 和 10 nM。AF-DX 384 可逆轉(zhuǎn)老年大鼠以及東莨菪堿誘導(dǎo)的幼鼠在新物體識(shí)別和被動(dòng)回避方面的缺陷。
AF-DX-384; AF-DX384
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
AF-DX-384; AF-DX384
生產(chǎn)廠家
118290-26-9, AF-DX-384; AF-DX384 相關(guān)搜索:
- 抑制劑
- 化合物 AF-DX 384
- N-[2-[2-[(二丙基氨基)甲基]-1-哌啶基]乙基]-5,6-二氫-6-氧代-11H-吡啶并[2,3-B][1,4]苯并二氮雜卓-1-甲酰胺
- 化合物 T22555
- 118290-26-9
- 11H-Pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide, N-[2-[2-[(dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-
- N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
- N-[2-[2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxo-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
- AF-DX-384; AF-DX384
- AF-DX 384 Free Base