CB-103 NEW
| Price | $33 |
| Package | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-29 |
Product Details
| Product Name: CB-103 | CAS No.: 218457-67-1 |
| Purity: 99.69% | Supply Ability: 10g |
| Release date: 2026/05/29 |
Product Introduction
Bioactivity
| Name | CB-103 |
| Description | CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity. |
| In vitro | CB-103 has shown the ability to block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines, and exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines[2]. |
| In vivo | CB-103inhibits growth of GSI/Mab resistant triple negative breast cancer, andexhibits anti-tumor activity in xenograft models of human T-ALL and mouse mammary tumors[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 240 mg/mL (990.43 mM), Sonication is recommended. 10% DMSO+90% Saline : < 10 mg/mL (41.27 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 2.5 mg/mL (10.32 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (41.27 mM), Solution. |
| Keywords | signaling | pathway | Notch | leukemia | Inhibitor | inhibit | Gammasecretase | CB-103 | CB103 | CB 103 |
| Inhibitors Related | Valproic acid sodium salt | Aβ42-IN-2 | Sulindac sulfide | Tangeretin | gamma-secretase modulator 1 | Valproic Acid | Nirogacestat | Hexamethylene bisacetamide | Gossypolone | Prednisone acetate | Carvacrol | RO7185876 |
| Related Compound Libraries | Anti-Colorectal Cancer Compound Library | Failed Clinical Trials Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Pediatric Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Orally Active Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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