2-胍基琥珀酸
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- CAS號(hào):
- 6133-30-8
- 英文名:
- GUANIDINOSUCCINIC ACID
- 英文別名:
- NSC49078;NSC 49078;NSC-49078;guanidinosuccic acid;n-amidino-asparticaci;GUANIDINOSUCCINIC ACID;N-amidinoaspartic acid;N-amidino-L-asparticaci;2-Guanidinosuccinic acid;L-N-Amidinoaspartic acid
- 中文名:
- 2-胍基琥珀酸
- 中文別名:
- 胍丁二酸;胍基琥珀酸;L-胍基丁二酸;2-胍基琥珀酸;(S)-2-胍基琥珀酸;(S)-2-胍基丁二酸;胍基琥珀酸,10 MM DMSO 溶液;6133-30-8;Guanidinosuccinic acid
- CBNumber:
- CB2710712
- 分子式:
- C5H9N3O4
- 分子量:
- 175.14
- MOL File:
- 6133-30-8.mol
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2-胍基琥珀酸化學(xué)性質(zhì)
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沸點(diǎn):
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344.5±52.0 °C(Predicted)
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密度:
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1.74±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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2-8°C
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溶解度:
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DMSO: 1 mg/ml; PBS (pH 7.2): 5 mg/ml
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形態(tài):
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A solid
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酸度系數(shù)(pKa):
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3.22±0.23(Predicted)
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顏色:
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White to off-white
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2-胍基琥珀酸性質(zhì)、用途與生產(chǎn)工藝
Guanidinosuccinic acid 是從血清和尿液中分離出的含氮代謝物，在尿毒癥患者的尿液和血清中升高。
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Human Endogenous Metabolite
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Guanidinosuccinic acid, a constituent of normal urine, is elevated in the urine and serum of azotemic patients. Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, is administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old. Epileptogenic and toxic properties are assessed and Guanidinosuccinic acid brain levels following i.p. injection ae determined. In adult mice, Guanidinosuccinic acid induces long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD
50
(and 95% confidence interval) of 363 (287-458) mg/kg (n=35), and an LD
50
of 579 (445-756) mg/kg. The CD
50
of Guanidinosuccinic acid corresponded with a brain concentration of 56 nmol/g tissue. Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions, When young mice are i.p. injected with a (for adults) subconvulsive dose of Guanidinosuccinic acid (250 mg/kg), an age-dependent decrease is noted in Guanidinosuccinic acid-induced convulsions and in the resulting brain concentration.
2-胍基琥珀酸
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-113373 | 2-胍基琥珀酸
Guanidinosuccinic acid | 6133-30-8 | 10mg | 350元 |
| 2026/06/05 | HY-113373 | 2-胍基琥珀酸
Guanidinosuccinic acid | 6133-30-8 | 10mM * 1mLin DMSO | 385元 |
6133-30-8, 2-胍基琥珀酸 相關(guān)搜索:
- amino acids
- 化學(xué)試劑
- 抑制劑
- 藥靶配體
- 有機(jī)化學(xué)品
- Modified Amino Acids
- Biochemicals and Reagents
- BioChemical
- Amino Acids and Peptides
- A - H
- C5H9N3O4
- C5H9O4N3
- 6133-30-8;Guanidinosuccinic acid
- 胍基琥珀酸,10 MM DMSO 溶液
- 胍丁二酸
- (S)-2-胍基丁二酸
- L-胍基丁二酸
- 胍基琥珀酸
- (S)-2-胍基琥珀酸
- 2-胍基琥珀酸
- 6133-30-8
- Guanidinosuccinic acid, 10 mM in DMSO
- NSC-49078
- NSC49078
- NSC 49078
- L-N-Amidinoaspartic acid
- N-amidino-L-asparticaci
- Inhibitor,Endogenous Metabolite,Guanidinosuccinic acid,inhibit
- N-amidinoaspartic acid
- N-carbamimidoyl-L-aspartic acid
- (S)-2-Guanidinosuccinic acid
- n-amidino-asparticaci
- n-(aminoiminomethyl)-l-asparticaci
- alpha-guanidinosuccinicacid
- N-AMIDINO-L-ASPARTIC ACID
- GUANIDINOSUCCINIC ACID
- (S)-GUANIDINOSUCCINIC ACID dihydrobromide
- guanidinosuccic acid
- (S)-GUANIDINOSUCCINIC ACID
- 2-Guanidinosuccinic acid
- L-ASPARTICACID,N-(AMINOIMINOMETHYL)-
- (2S)-2-(diaminomethylideneamino)butanedioic acid