阿佐昔芬鹽酸鹽
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- CAS號:
- 182133-27-3
- 英文名:
- ARZOXIFENE HCL
- 英文別名:
- Serm 3;Ly 353381;Ly 353381 HCl;ARZOXIFENE HCL;Arzoxifene hydrochloride;NHSNLUIMAQQXGR-UHFFFAOYSA-N;Arzoxifene (hydrochloride salt);2-(p-Methoxyphenyl)-3-(p-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride;2-(4-Methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride;Benzo(B)thiophene-6-ol, 2-(4-methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)-, hydrochloride
- 中文名:
- 阿佐昔芬鹽酸鹽
- 中文別名:
- 阿佐昔芬鹽酸鹽;化合物 T10379;化合物 ARZOXIFENE HYDROCHLORIDE
- CBNumber:
- CB31515928
- 分子式:
- C28H29NO4S.ClH
- 分子量:
- 512.067
- MOL File:
- 182133-27-3.mol
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阿佐昔芬鹽酸鹽化學性質
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熔點:
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156-160°
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形態(tài):
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Solid
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顏色:
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Off-white to light yellow
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阿佐昔芬鹽酸鹽性質、用途與生產(chǎn)工藝
Arzoxifene hydrocloride是一種選擇性的雌激素受體 (estrogen receptor) 調節(jié)劑，它是乳腺和子宮組織中有效的雌激素拮抗劑，同時作為維持骨密度和降低血清膽固醇的雌激素激動劑。
Arzoxifene inhibits cell growth as effectively as the antiestrogen tamoxifen. Northern analysis reveals that arzoxifene exerts a statistically significant inhibition of pS2 and progesterone receptor B mRNA expression. Significant agonistic effect is observed on the antitrypsin mRNA expression. In contrast to estradiol and tamoxifen, arzoxifene does not upregulate cathepsin D mRNA and protein expression.
Arzoxifene prevents the ovariectomy-induced increase in body weight and serum cholesterol levels of treated rats and lowers them to below sham levels in a dose dependent manner, with maximum efficacy similar to estrogen or raloxifene. Arzoxifene (LY353381.HCl) prevents loss of bone due to ovariectomy with an ED
50
of about 0.01 mg/kg with maximal efficacy observed at 0.1-1 mg/kg/day. Arzoxifene (LY353381.HCl) antagonizes the estrogen-induced elevation in uterine weight down to vehicle-dosed control levels with ED
50
of 0.03 mg/kg/day.
阿佐昔芬鹽酸鹽
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/06/05 | HY-13556A | 阿佐昔芬鹽酸鹽
Arzoxifene hydrochloride | 182133-27-3 | 1 mg | 3600元 |
| 2026/06/05 | HY-13556A | 阿佐昔芬鹽酸鹽
Arzoxifene hydrochloride | 182133-27-3 | 10 mM * 1 mL in DMSO | 10139元 |
182133-27-3, 阿佐昔芬鹽酸鹽 相關搜索:
- 抑制劑
- C28H29NO4SHCl
- 化合物 ARZOXIFENE HYDROCHLORIDE
- 化合物 T10379
- 阿佐昔芬鹽酸鹽
- 182133-27-3
- Arzoxifene (hydrochloride salt)
- NHSNLUIMAQQXGR-UHFFFAOYSA-N
- Serm 3
- Ly 353381 HCl
- Ly 353381
- Benzo(B)thiophene-6-ol, 2-(4-methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)-, hydrochloride
- Arzoxifene hydrochloride
- 2-(p-Methoxyphenyl)-3-(p-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride
- 2-(4-Methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride
- ARZOXIFENE HCL