PKCε Inhibitor Peptide
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- CAS號(hào):
- 182683-50-7
- 英文名:
- PKCε Inhibitor Peptide
- 英文別名:
- ε-V1-2;epsilonV1-2;KNTBAGOTDJPUJV-XMTFRXHISA-N;L-a-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine;L-α-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine;L-Threonine, L-α-glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-
- 中文名:
- PKCε Inhibitor Peptide
- 中文別名:
- Ε-V1-2; EAVSLKPT;PKCΕ抑制劑多肽EPSILON-V1-2;EPSILON-V1-2 |CAS 182683-50-7
- CBNumber:
- CB33152716
- 分子式:
- C37H65N9O13
- 分子量:
- 843.96
- MOL File:
- 182683-50-7.mol
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PKCε Inhibitor Peptide化學(xué)性質(zhì)
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沸點(diǎn):
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1280.1±65.0 °C(Predicted)
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密度:
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1.288±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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DMSO: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
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形態(tài):
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A crystalline solid
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酸度系數(shù)(pKa):
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3.28±0.10(Predicted)
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顏色:
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White to off-white
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PKCε Inhibitor Peptide性質(zhì)、用途與生產(chǎn)工藝
Epsilon-V1-2 (ε-V1-2) 是一種 PKCε 衍生肽，是一種選擇性 PKCε 抑制劑。Epsilon-V1-2 抑制 PKCε 的轉(zhuǎn)運(yùn)，但不抑制 α-，β- 和 δPKC 的轉(zhuǎn)運(yùn)。
Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide containing the site for its specific receptor for activated C kinase (RACK), inhibits translocation of PKCε and reduces insulin response to glucose.
Epsilon-V1-2 (ε-V1-2; 1 μM, 24 hours) treatment significantly inhibits Oleic acid (OA)-induced connexin 43 (Cx43) Ser368 phosphorylation and prevents OA-induced gap junction disassembly in cardiomyocytes.
Epsilon-V1-2 (20 mg/kg/day; osmotic pumps; daily; for 4 weeks) treatment significantly improves the beating score in a murine heterotopic transplantation model. Epsilon-V1-2 reduces infiltration of macrophages and T cells into the cardiac grafts, and decreases parenchymal fibrosis. Epsilon-V1-2 treatment almost abolishes the rise in pro-fibrotic cytokine, TGF-β and monocyte recruiting chemokine MCP-1 levels.
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Animal Model:
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C57BL/6J mice transplanted the hearts of FVB mice
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Dosage:
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20 mg/kg/day
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Administration:
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0.1 mL osmotic pumps implanted subcutaneously; daily; for 4 weeks
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Result:
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Significantly improved the beating score throughout the treatment.
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PKCε Inhibitor Peptide
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-P0154 | PKCε Inhibitor Peptide
Epsilon-V1-2 | 182683-50-7 | 5mg | 1800元 |
| 2026/06/05 | HY-P0154 | PKCε Inhibitor Peptide
Epsilon-V1-2 | 182683-50-7 | 10mg | 3200元 |
PKCε Inhibitor Peptide
生產(chǎn)廠家
182683-50-7, PKCε Inhibitor Peptide 相關(guān)搜索:
- 抑制劑
- 目錄肽
- EPSILON-V1-2 |CAS 182683-50-7
- Ε-V1-2; EAVSLKPT
- PKCΕ抑制劑多肽EPSILON-V1-2
- 182683-50-7
- ε-V1-2
- L-Threonine, L-α-glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-
- L-a-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine
- epsilonV1-2
- L-α-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine
- KNTBAGOTDJPUJV-XMTFRXHISA-N