奴文西平
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- CAS號:
- 96487-37-5
- 英文名:
- Nuvenzepine
- 英文別名:
- K-545;Nuvenzepine;11-(1-methylpiperidine-4-carbonyl)-6H-pyrido[3,2-c][1,5]benzodiazepin-5-one;11-(1-Methylpiperidine-4-carbonyl)-6,11-dihydro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-5-one;6,11-Dihydro-11-[(1-methyl-4-piperidinyl)carbonyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one;5H-Pyrido[2,3-b][1,5]benzodiazepin-5-one, 6,11-dihydro-11-[(1-methyl-4-piperidinyl)carbonyl]-
- 中文名:
- 奴文西平
- 中文別名:
- 奴文西平;化合物 T16362;化合物 NUVENZEPINE;11-(1-甲基哌啶-4-羰基)-6,11-二氫-5H-苯并[b]吡啶并[2,3-e][1,4]二氮雜卓-5-酮
- CBNumber:
- CB41118339
- 分子式:
- C19H20N4O2
- 分子量:
- 336.39
- MOL File:
- 96487-37-5.mol
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奴文西平化學(xué)性質(zhì)
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沸點:
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522.3±50.0 °C(Predicted)
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密度:
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1.267±0.06 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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10.99±0.20(Predicted)
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顏色:
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White to off-white
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奴文西平性質(zhì)、用途與生產(chǎn)工藝
Nuvenzepine是 mAChR 的拮抗劑，有潛力用于胃痙攣的研究。
Nuvenzepine shows a four-fold higher affinity than pirenzepine in competitively antagonizing acetylcholine-induced contractions on isolated ileal musculature and on longitudinal ileum dispersed cells. Nuvenzepine is almost equipotent to pirenzepine in competitively preventing bethanechol-induced gall-bladder contractions and it displays a four-fold higher potency than pirenzepine in blocking vagal-stimulated tracheal constrictions.
Intraduodenally administration of Nuvenzepine displays a long-lasting and dose-dependent inhibition of neostigmine-induced intestinal motility in anaesthetized cats. On ileal motor activity, Nuvenzepine shows a potency 10 times greater than that of pirenzepine. Nuvenzepine is also active, unlike pirenzepine, on colonic stimulated motility. Furthermore, in conscious cats, Nuvenzepine inhibits pentagastrin-stimulated gastric acid secretion resulting 25-30 times more potent than pirenzepine. Nuvenzepine has been found to be very active in inhibiting gastric acid secretion and intestinal hypermotility in rats, with very slight atropine-like side effects. The oral absorption rate is relatively slow, that the absolute bioavailability is 30 to 40%, that the elimination rate is slow and there is no accumulation in the body, and that there is very little metabolism.
奴文西平
上下游產(chǎn)品信息
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下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/06/05 | HY-U00119 | 奴文西平
Nuvenzepine | 96487-37-5 | 1mg | 1800元 |
| 2026/06/05 | HY-U00119 | 奴文西平
Nuvenzepine | 96487-37-5 | 5mg | 4000元 |
96487-37-5, 奴文西平 相關(guān)搜索:
- 抑制劑
- 11-(1-甲基哌啶-4-羰基)-6,11-二氫-5H-苯并[b]吡啶并[2,3-e][1,4]二氮雜卓-5-酮
- 化合物 NUVENZEPINE
- 化合物 T16362
- 奴文西平
- 96487-37-5
- 11-(1-Methylpiperidine-4-carbonyl)-6,11-dihydro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-5-one
- 11-(1-methylpiperidine-4-carbonyl)-6H-pyrido[3,2-c][1,5]benzodiazepin-5-one
- 5H-Pyrido[2,3-b][1,5]benzodiazepin-5-one, 6,11-dihydro-11-[(1-methyl-4-piperidinyl)carbonyl]-
- K-545
- 6,11-Dihydro-11-[(1-methyl-4-piperidinyl)carbonyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one
- Nuvenzepine