4-氯-6,7-二氫-5H-環(huán)戊二烯并[B]吡啶
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- CAS號(hào):
- 54664-55-0
- 英文名:
- 5H-Cyclopenta[b]pyridine, 4-chloro-6,7-dihydro-
- 英文別名:
- 7-Dihydro-5H-cyclopenta[b]pyridine;6,7-Dihydro-5H-[1]pyrindin-4-ylaMine;5H-1-Pyrindine, 4-chloro-6,7-dihydro-;4-CHLORO-6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDINE;5H-Cyclopenta[b]pyridine, 4-chloro-6,7-dihydro-;4-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine 98%;5H-Cyclopenta[b]pyridine, 4-chloro-6,7-dihydro- ISO 9001：2015 REACH
- 中文名:
- 4-氯-6,7-二氫-5H-環(huán)戊二烯并[B]吡啶
- 中文別名:
- 4-氯-6,7-二氫-5h-環(huán)戊[b]吡啶;4-氯-6,7-二氫-5H-環(huán)戊并[b]吡啶;4-氯-6,7-二氫-5H-環(huán)戊烷并[B]吡啶;4-氯-6,7-二氫-5H-環(huán)戊二烯并[B]吡啶
- CBNumber:
- CB41512348
- 分子式:
- C8H8ClN
- 分子量:
- 153.61
- MOL File:
- 54664-55-0.mol
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4-氯-6,7-二氫-5H-環(huán)戊二烯并[B]吡啶化學(xué)性質(zhì)
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沸點(diǎn):
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234℃
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密度:
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1.241
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閃點(diǎn):
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118℃
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儲(chǔ)存條件:
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under inert gas (nitrogen or Argon) at 2-8°C
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酸度系數(shù)(pKa):
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4.34±0.20(Predicted)
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外觀:
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Colorless to light yellow Liquid
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4-氯-6,7-二氫-5H-環(huán)戊二烯并[B]吡啶性質(zhì)、用途與生產(chǎn)工藝
生產(chǎn)方法
以6,7-二氫-5H-環(huán)戊二烯并[b]吡啶1-氧化物（2.5g，18mmol）為原料，與磷酰氯（20mL，200mmol）混合。將反應(yīng)混合物在120℃下攪拌3小時(shí)。反應(yīng)完成后，通過(guò)減壓蒸餾除去過(guò)量的POCl3。將殘余物用80mL EtOAc稀釋，并用Na2CO3溶液中和至pH 7-8。過(guò)濾后，水層用EtOAc萃取兩次（每次40mL）。合并有機(jī)萃取液，用無(wú)水Na2SO4干燥，過(guò)濾并減壓濃縮，得到4-氯-6,7-二氫-5H-環(huán)戊二烯并[b]吡啶（2.6g，收率93%）。LCMS分析：C8H9ClN（M + H）+的計(jì)算值：m/z = 154.2；實(shí)測(cè)值：154.3。
參考文獻(xiàn)：
[1] Patent: US2014/200216, 2014, A1. Location in patent: Paragraph 0532; 0533
[2] Patent: US2014/200227, 2014, A1. Location in patent: Paragraph 0641; 0642
[3] Patent: WO2016/196244, 2016, A1. Location in patent: Page/Page column 195
[4] Patent: WO2009/19274, 2009, A1. Location in patent: Page/Page column 32
[5] Advanced Synthesis and Catalysis, 2007, vol. 349, # 14-15, p. 2345 - 2352
4-氯-6,7-二氫-5H-環(huán)戊二烯并[B]吡啶
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
4-氯-6,7-二氫-5H-環(huán)戊二烯并[B]吡啶
生產(chǎn)廠家
4-氯-6,7-二氫-5H-環(huán)戊二烯并[B]吡啶 圖譜信息:
54664-55-0, 4-氯-6,7-二氫-5H-環(huán)戊二烯并[B]吡啶 相關(guān)搜索:
- Heterocycle-Pyridine series
- 有機(jī)化學(xué)
- 4-氯-6,7-二氫-5h-環(huán)戊[b]吡啶
- 4-氯-6,7-二氫-5H-環(huán)戊并[b]吡啶
- 4-氯-6,7-二氫-5H-環(huán)戊烷并[B]吡啶
- 4-氯-6,7-二氫-5H-環(huán)戊二烯并[B]吡啶
- 54664-55-0
- 5H-Cyclopenta[b]pyridine, 4-chloro-6,7-dihydro- ISO 9001：2015 REACH
- 4-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridine 98%
- 5H-1-Pyrindine, 4-chloro-6,7-dihydro-
- 6,7-Dihydro-5H-[1]pyrindin-4-ylaMine
- 7-Dihydro-5H-cyclopenta[b]pyridine
- 4-CHLORO-6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDINE
- 5H-Cyclopenta[b]pyridine, 4-chloro-6,7-dihydro-