1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone
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- CAS號:
- 865449-63-4
- 英文名:
- 1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone
- 英文別名:
- 1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethan-1-one;4-Bromo-5-fluoro-2-hydroxyacetophenone;1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone;Ethanone, 1-(4-bromo-5-fluoro-2-hydroxyphenyl)-
- 中文名:
- 1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone
- 中文別名:
- 183121;4-溴-5-氟-2-羥基苯乙酮;1-(4-溴-5-氟-2-羥基苯基)乙酮
- CBNumber:
- CB41555987
- 分子式:
- C8H6BrFO2
- 分子量:
- 233.03
- MOL File:
- 865449-63-4.mol
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1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone化學(xué)性質(zhì)
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沸點(diǎn):
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302.7±42.0 °C(Predicted)
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密度:
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1.667±0.06 g/cm3(Predicted)
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儲存條件:
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Sealed in dry,Room Temperature
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酸度系數(shù)(pKa):
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9.23±0.23(Predicted)
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外觀:
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Off-white to yellow Solid
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1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone性質(zhì)、用途與生產(chǎn)工藝
生產(chǎn)方法
以3-溴-4-氟苯乙酸酯為起始原料合成1-(4-溴-5-氟-2-羥基苯基)乙酮的一般步驟如下：將3-溴-4-氟苯基乙酸酯（5.5 g，23 mmol）溶解于三氟化硼乙酸絡(luò)合物（47 mL，340 mmol）中，于155℃下加熱反應(yīng)14小時。反應(yīng)完成后，將反應(yīng)混合物冷卻至0℃，并加入冰水處理。待冰浴移除后，讓冰自然融化。隨后，用冷水稀釋反應(yīng)混合物，并進(jìn)行過濾。收集的固體用冷水洗滌，并在空氣中干燥。將干燥后的產(chǎn)物吸附于硅膠上，采用快速柱色譜法進(jìn)行純化，洗脫劑為梯度比例的己烷/乙酸乙酯（0%-30%），最終得到目標(biāo)產(chǎn)物1-(4-溴-5-氟-2-羥基苯基)乙酮（4.0 g，收率73%）。需注意的是，該產(chǎn)物在質(zhì)譜分析中未觀察到電離信號。
參考文獻(xiàn)：
[1] Patent: WO2011/75630, 2011, A1. Location in patent: Page/Page column 107
[2] Patent: US2005/209274, 2005, A1. Location in patent: Page/Page column 42
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 19, p. 4851 - 4856
[4] Patent: EP3381896, 2018, A1. Location in patent: Paragraph 0455
1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/06/05 | XW0286544963403 | 1-(4-溴-5-氟-2-羥基苯基)乙酮
1-(4-Bromo-5-fluoro-2-hydroxyphenyl)ethanone | 865449-63-4 | 1g | 409元 |
| 2026/06/05 | XW0286544963402 | 1-(4-溴-5-氟-2-羥基苯基)乙酮
1-(4-Bromo-5-fluoro-2-hydroxyphenyl)ethanone | 865449-63-4 | 250mg | 103元 |
1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone
生產(chǎn)廠家
1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone 圖譜信息:
865449-63-4, 1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone 相關(guān)搜索:
- 苯環(huán)
- 4-溴-5-氟-2-羥基苯乙酮
- 183121
- 1-(4-溴-5-氟-2-羥基苯基)乙酮
- 865449-63-4
- 1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethan-1-one
- 4-Bromo-5-fluoro-2-hydroxyacetophenone
- Ethanone, 1-(4-bromo-5-fluoro-2-hydroxyphenyl)-
- 1-(4-bromo-5-fluoro-2-hydroxyphenyl)ethanone