615253-61-7
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- CAS號:
- 615253-61-7
- 英文名:
- SP187
- 英文別名:
- UV4);SP187;UV-4B;MON-?DNJ;SP-187,SP187;SP187 (MON-?DNJ;SP187, 10 mM in DMSO;3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-(9-methoxynonyl)-, (2R,3R,4R,5S)-
- 中文名:
- 615253-61-7
- 中文別名:
- 化合物 SP187;化合物 T16914;化合物SP187,10 MM DMSO 溶液;(2R,3R,4R,5S)-2-(羥甲基)-1-(9-甲氧基壬基)哌啶-3,4,5-三醇
- CBNumber:
- CB43339714
- 分子式:
- C16H33NO5
- 分子量:
- 319.44
- MOL File:
- 615253-61-7.mol
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615253-61-7化學(xué)性質(zhì)
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沸點:
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475.0±40.0 °C(Predicted)
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密度:
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1.128±0.06 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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13.72±0.70(Predicted)
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顏色:
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White to off-white
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615253-61-7性質(zhì)、用途與生產(chǎn)工藝
SP187 是一種靶向作用于宿主的針對絲狀病毒感染的亞胺糖。SP187 在體內(nèi)抗流感和登革熱。
IC50: 29.97 μM (EBOV), 47.72 μM (MARV)
The antiviral activity of iminosugar SP187 (UV-4) in vitro against EBOV and MARV is assessed using a yield-plaque assay format and the IC
50
is determined. Antiviral activity for SP187 is observed with IC
50
of 29.97 and 47.72 μM for EBOV and MARV, respectively.
The efficacy of SP187 (UV-4), the active free base component of UV-4B, and UV-5, the most potent iminosugar tested in vitro, is first assessed using a mouse model of EBOV infection. In this study, C57Bl/6 mice are administered 10 or 100 mg/kg of SP187 or UV-5 via oral gavage or IP injection. Dosing started ~1h before infection with ~1000 pfu of mouse-adapted EBOV and is repeated BID for 10 days at approximately 12 hour intervals for UV-5 or TID at approximately 8 hour intervals for SP187. The selected doses and schedule are based on tolerability studies in na?ve mice. No efficacy is observed in the iminosugar treated mice as compared to the vehicle control.
615253-61-7
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下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2026/06/05 | HY-U00160 | 615253-61-7
SP187 | 615253-61-7 | 5mg | 2000元 |
| 2026/06/05 | HY-U00160 | 615253-61-7
SP187 | 615253-61-7 | 10 mM * 1 mLin DMSO | 2200元 |
615253-61-7, 615253-61-7 相關(guān)搜索:
- 抑制劑
- C16H33NO5
- (2R,3R,4R,5S)-2-(羥甲基)-1-(9-甲氧基壬基)哌啶-3,4,5-三醇
- 化合物SP187,10 MM DMSO 溶液
- 化合物 SP187
- 化合物 T16914
- 615253-61-7
- SP187, 10 mM in DMSO
- SP-187,SP187
- SP187 (MON-?DNJ
- UV4)
- MON-?DNJ
- UV-4B
- 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-(9-methoxynonyl)-, (2R,3R,4R,5S)-
- SP187