HS-10296 HYDROCHLORIDE
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- CAS號(hào):
- 2134096-03-8
- 英文名:
- HS-10296 hydrochloride
- 英文別名:
- Almonertinib HCl;HS-10296 hydrochloride;Almonertinib (hydrochloride);Almonertinib (HS-10296) hydrochloride;Almonertinib hydrochloride (HS-10296 hydrochloride);N-(5-((4-(1-CYCLOPROPYL-1H-INDOL-3-YL)PYRIMIDIN-2-YL)AMINO)-2-((2-(DIMETHYLAMINO)ETHYL)(METHYL)AMINO)-4-METHOXYPHENYL)ACRYLAMIDE HYDROCHLORIDE;HS10296,EGFR,non-small,inhibit,oral,cancer,lung,del19,antineoplastic,HS-10296,mutations,Epidermal growth factor receptor,L861Q,Almonertinib hydrochloride,G719X,Inhibitor,NSCLC,ErbB-1,L858R,cell,Almonertinib,HS 10296,HER1
- 中文名:
- HS-10296 HYDROCHLORIDE
- 中文別名:
- 鹽酸阿美替尼;阿美替尼鹽酸鹽;化合物HS-10296 HYDROCHLORIDE;N-(5-((4-(1-環(huán)丙基-1H-吲哚-3-基)嘧啶-2-基)氨基)-2-((2-(二甲氨基)乙基)(甲基)氨基)-4-甲氧基苯基)丙烯酰胺鹽酸鹽
- CBNumber:
- CB44844873
- 分子式:
- C30H36ClN7O2
- 分子量:
- 562.12
- MOL File:
- 2134096-03-8.mol
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HS-10296 HYDROCHLORIDE化學(xué)性質(zhì)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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DMSO:83.33(Max Conc. mg/mL);148.24(Max Conc. mM)
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形態(tài):
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Solid
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顏色:
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Off-white to yellow
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HS-10296 HYDROCHLORIDE性質(zhì)、用途與生產(chǎn)工藝
Almonertinib (HS-10296) hydrochloride 是一種口服、不可逆的第三代 EGFR 酪氨酸激酶抑制劑，對(duì) EGFR 致敏和 T790M 耐藥突變具有高選擇性。Almonertinib hydrochloride 對(duì) T790M、T790M/L858R 和 T790M/Del19 表現(xiàn)出較強(qiáng)的抑制活性 (IC50 分別為 0.37、0.29 和 0.21 nM)，對(duì)野生型的抑制作用較弱 (3.39 nM)。Almonertinib hydrochloride 用于非小細(xì)胞肺癌的研究。
HS-10296 HYDROCHLORIDE
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-112823B | Almonertinib hydrochloride | 2134096-03-8 | 1 mg | 420元 |
| 2026/06/05 | HY-112823B | HS-10296 HYDROCHLORIDE
Almonertinib hydrochloride | 2134096-03-8 | 5mg | 1050元 |
HS-10296 HYDROCHLORIDE
生產(chǎn)廠家
HS-10296 HYDROCHLORIDE 圖譜信息:
2134096-03-8, HS-10296 HYDROCHLORIDE 相關(guān)搜索:
- 抑制劑
- N-(5-((4-(1-環(huán)丙基-1H-吲哚-3-基)嘧啶-2-基)氨基)-2-((2-(二甲氨基)乙基)(甲基)氨基)-4-甲氧基苯基)丙烯酰胺鹽酸鹽
- 鹽酸阿美替尼
- 阿美替尼鹽酸鹽
- 化合物HS-10296 HYDROCHLORIDE
- 2134096-03-8
- Almonertinib HCl
- Almonertinib hydrochloride (HS-10296 hydrochloride)
- HS10296,EGFR,non-small,inhibit,oral,cancer,lung,del19,antineoplastic,HS-10296,mutations,Epidermal growth factor receptor,L861Q,Almonertinib hydrochloride,G719X,Inhibitor,NSCLC,ErbB-1,L858R,cell,Almonertinib,HS 10296,HER1
- Almonertinib (HS-10296) hydrochloride
- Almonertinib (hydrochloride)
- N-(5-((4-(1-CYCLOPROPYL-1H-INDOL-3-YL)PYRIMIDIN-2-YL)AMINO)-2-((2-(DIMETHYLAMINO)ETHYL)(METHYL)AMINO)-4-METHOXYPHENYL)ACRYLAMIDE HYDROCHLORIDE
- HS-10296 hydrochloride