糠酸二氯尼特
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- CAS號:
- 3736-81-0
- 英文名:
- Diloxanide furoate
- 英文別名:
- Furoate;furamide;8073cb;amebiazol;furentomin;histomibal;diclofurazol;dichlofurazol;entamidefuroate;diloxanidfuroate
- 中文名:
- 糠酸二氯尼特
- 中文別名:
- 糠酯酰胺;糠二氯散;三糠醛縮二胺;糠酸二氟尼特;糠酸二氯尼特;二氯尼特糠酸酯;三呋喃亞甲基二胺;化合物 T15131;4-(N-甲基-2,2-二氯乙酰氨基)苯基 2-糠酸酯;4-(2,2-二氯-N-甲基乙酰氨基)苯基 呋喃-2-羧酸酯
- CBNumber:
- CB4723149
- 分子式:
- C14H11Cl2NO4
- 分子量:
- 328.15
- MOL File:
- 3736-81-0.mol
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糠酸二氯尼特化學(xué)性質(zhì)
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熔點:
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111-114 °C
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沸點:
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438.4±45.0 °C(Predicted)
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密度:
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1.424±0.06 g/cm3(Predicted)
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儲存條件:
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2-8°C
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溶解度:
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Chloroform (Slightly), Methanol (Slightly)
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酸度系數(shù)(pKa):
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-0+-.0.50(Predicted)
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形態(tài):
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Solid
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顏色:
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Off-White to Light Beige
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BCS Class:
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4
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主要應(yīng)用:
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pharmaceutical (small molecule)
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InChI:
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1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3
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InChIKey:
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BDYYDXJSHYEDGB-UHFFFAOYSA-N
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SMILES:
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CN(C(=O)C(Cl)Cl)c1ccc(OC(=O)c2ccco2)cc1
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CAS 數(shù)據(jù)庫:
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3736-81-0(CAS DataBase Reference)
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糠酸二氯尼特性質(zhì)、用途與生產(chǎn)工藝
Diloxanide furoate 是二苯氧尼特的前藥。Diloxanide furoate 是一種有效的具有口服活性的抗原蟲制劑 (anti-protozoal agent)，可用于阿米巴病、輕度腸道阿米巴病或無癥狀包囊?guī)Ь腥镜南嚓P(guān)研究。
Diloxanide furoate (1.95-2.5 μg/ml) has potent activity against different strains of
E. histolytica
, it is against BYso (grown with bacteria), SFL3 (grown with Chrithidia sp.), and SFL3 (grown axenically) with MIC values of 2.5 μg/ml, 2.5 μg/ml and 1.95 μg/ml, respectively.
Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED
50
value is 77.9 mg/kg for this agent in rats.
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Animal Model:
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Weanling Wistar rats
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Dosage:
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200 mg/kg; 150 mg/kg; 100 mg/kg; 75 mg/kg
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Administration:
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Oral administraion; 75-200 mg/kg; 3 days; once daily
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Result:
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Was against intestinal (caecal) amoebiasis in rats.
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糠酸二氯尼特
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/06/05 | HY-B1147 | 糠酸二氯尼特
Diloxanide furoate | 3736-81-0 | 5 mg | 333元 |
| 2026/06/05 | HY-B1147 | 糠酸二氯尼特
Diloxanide furoate | 3736-81-0 | 10 mM * 1 mL in DMSO | 366元 |
3736-81-0, 糠酸二氯尼特 相關(guān)搜索:
- 小分子抑制劑
- 抑制劑
- 對照品
- 化工原料
- BioChemical
- Antibiotics
- Antibiotics A-F
- Antibiotics A to Z
- 376-81-0
- 4-(2,2-二氯-N-甲基乙酰氨基)苯基 呋喃-2-羧酸酯
- 化合物 T15131
- 糠酸二氟尼特
- 糠酸二氯尼特
- 4-(N-甲基-2,2-二氯乙酰氨基)苯基 2-糠酸酯
- 三糠醛縮二胺
- 三呋喃亞甲基二胺
- 二氯尼特糠酸酯
- 糠酯酰胺
- 糠二氯散
- 3736-81-0
- Furoate
- furamide
- Diloxanide Furoate (1204805)
- 2-Furancarboxylic acid, 4-[(2,2-dichloroacetyl)methylamino]phenyl ester
- 4-(2,2-Dichloro-N-MethylacetaMido)phenyl furan-2-carboxylate
- Diloxanide Furoate (200 mg)
- furan-2-carboxylic acid [4-[(2,2-dichloroacetyl)-methyl-amino]phenyl] ester
- [4-[2,2-dichloroethanoyl(methyl)amino]phenyl] furan-2-carboxylate
- [4-[(2,2-dichloroacetyl)-methylamino]phenyl] furan-2-carboxylate
- Diloxanide 2-furoic acid ester
- 4-[(dichloroacetyl)methylamino]phenyl 2-furoate
- histomibal
- furentomin
- furamide(amebicide)
- entamidefuroate
- entamide2-furoate
- diloxanidfuroate
- diclofurazol
- dichlofurazol
- amebiazol
- 8073cb
- 2-furoicacid,esterwith2,2-dichloro-4’-hydroxy-n-methylacetanilide
- 2-furancarboxylicacid,4-((dichloroacetyl)methylamino)phenylester
- DILOXANIDE FUROATE
- 2,2-DICHLORO-N-(4-HYDROXYPHENYL)-N-METHYLACETAMIDE 2-FUROIC ACID ESTER