4,4'-(dithiodicarbonothioyl)dimorpholine
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- CAS號:
- 729-46-4
- 英文名:
- 4,4'-(dithiodicarbonothioyl)dimorpholine
- 英文別名:
- JX 06;JX06 ，S0983;JX06, 10 mM in DMSO;Bis(morpholinothiocarbonyl) disulfide;DI(4-MORPHOLINYL)DITHIOPEROXYANHYDRIDE;Bis(morpholinocarbonothioyl) persulfide;4,4'-(dithiodicarbonothioyl)dimorpholine;Morpholine, 4,4-(dithiodicarbonothioyl)bis-;Apoptosis,JX06,JX-06,Inhibitor,PDH kinase,inhibit,Pyruvate dehydrogenase kinase,JX 06,PDHK
- 中文名:
- 4,4'-(dithiodicarbonothioyl)dimorpholine
- 中文別名:
- JX06 試劑;JX06 試劑;化合物JX06;JX06 ,S0983;雙(嗎啉硫代羰基)二硫化物;雙(嗎啉噻吩羰基)二硫化物;雙(嗎啉硫代羰基)二硫化物/JX06;雙(嗎啉硫代羰基)二硫化物/JX06;化合物JX06,10 MM DMSO 溶液;雙(嗎啉代硫代羰基)二硫化物(JX 06)
- CBNumber:
- CB4875824
- 分子式:
- C10H16N2O2S4
- 分子量:
- 324.51
- MOL File:
- 729-46-4.mol
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4,4'-(dithiodicarbonothioyl)dimorpholine化學(xué)性質(zhì)
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熔點(diǎn):
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136-137 °C
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沸點(diǎn):
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466.3±55.0 °C(Predicted)
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密度:
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1.4302 (rough estimate)
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折射率:
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1.5650 (estimate)
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儲存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形態(tài):
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A solid
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酸度系數(shù)(pKa):
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0.58±0.20(Predicted)
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顏色:
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White to off-white
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EPA化學(xué)物質(zhì)信息:
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Morpholine, 4,4'-(dithiodicarbonothioyl)bis- (729-46-4)
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4,4'-(dithiodicarbonothioyl)dimorpholine性質(zhì)、用途與生產(chǎn)工藝
JX06 是一種細(xì)胞中的 PDK1 的選擇性共價抑制劑。JX06 可劑量依賴性地抑制PDK1、PDK2和PDK3，對應(yīng)的IC50值分別為0.049 μM、0.101 μM 和 0.313 μM。
| Target | Value |
PDK1
(Cell-free assay)
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0.049 μM
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PDK2
(Cell-free assay)
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0.101 μM
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PDK3
(Cell-free assay)
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0.313 μM
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JX06 barely shows inhibitory activity against PDK4 at a concentration of 10 μM.
JX06 (1-10 μM; 48 hours) induces cell apoptosis in cancer cells with high ECAR/OCR.
JX06 (0-0.6 μM; 72 hours) dose-dependently suppresses the growth of A549 cells.
JX06 (0.1-10 μM; 6-24 hours) inhibits PDHA1 phosphorylation in A549 cells in a time- and dose-dependent manner.
JX06 (1-10 μM) increases glucose uptake and intracellular ATP level and reduces aerobic glycolysis determined by the lactate production in A549 cells.
JX06 (1-10 μM; 24 hours) induces ROS generation in cancer cells with high extracellular acidification rate (ECAR)/ oxygen consumption rate (OCR) .
Apoptosis Analysis
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Cell Line:
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A549, EBC-1, HT-29 and H460 cells
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Concentration:
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0, 1, 3, 10 μM
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Incubation Time:
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48 hours
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Result:
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Induces cell apoptosis in A549 and EBC-1 cells.
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Cell Viability Assay
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Cell Line:
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A549 cells
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Concentration:
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0, 0.2, 0.4, 0.6 μM
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Incubation Time:
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72 hours
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Result:
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Inhibits the viability of A549 cells in a dose dependent manner.
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Western Blot Analysis
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Cell Line:
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A549 cells
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Concentration:
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0, 0.1, 0.3, 1, 3, 10 μM
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Incubation Time:
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0, 6, 12, 24 hours
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Result:
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Decreased PDHA1 phosphorylation at both serine 293 and serine 232 (S293 and S232) in a time- and dose-dependent manner.
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JX06 (40-80?mg/kg; i.p. for 21 days) inhibits tumor growth in vivo.
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Animal Model:
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A549 subcutaneous xenograft mice
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Dosage:
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40, 80?mg/kg
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Administration:
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I.p. injections for 21 days
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Result:
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Reduced tumor weights and 67.5% tumor volume at the dose of 80 mg/kg compared with the vehicle control.
Well tolerated at the administration dose.
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4,4'-(dithiodicarbonothioyl)dimorpholine
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/06/05 | HY-19564 | 4,4'-(dithiodicarbonothioyl)dimorpholine
JX06 | 729-46-4 | 5mg | 420元 |
| 2026/06/05 | HY-19564 | 4,4'-(dithiodicarbonothioyl)dimorpholine
JX06 | 729-46-4 | 10mM * 1mLin DMSO | 462元 |
4,4'-(dithiodicarbonothioyl)dimorpholine
生產(chǎn)廠家
4,4'-(dithiodicarbonothioyl)dimorpholine 圖譜信息:
729-46-4, 4,4'-(dithiodicarbonothioyl)dimorpholine 相關(guān)搜索:
- 化學(xué)試劑
- 藥靶配體
- 抑制劑
- C10H16N2O2S4
- JX06 試劑
- 雙(嗎啉硫代羰基)二硫化物/JX06
- JX06 ,S0983
- JX06 試劑
- 雙(嗎啉硫代羰基)二硫化物/JX06
- 化合物JX06,10 MM DMSO 溶液
- 雙(嗎啉噻吩羰基)二硫化物
- 雙(嗎啉代硫代羰基)二硫化物(JX 06)
- 雙(嗎啉硫代羰基)二硫化物
- 化合物JX06
- 729-46-4
- JX06 ，S0983
- DI(4-MORPHOLINYL)DITHIOPEROXYANHYDRIDE
- JX06, 10 mM in DMSO
- Apoptosis,JX06,JX-06,Inhibitor,PDH kinase,inhibit,Pyruvate dehydrogenase kinase,JX 06,PDHK
- Bis(morpholinothiocarbonyl) disulfide
- JX 06
- Bis(morpholinocarbonothioyl) persulfide
- Morpholine, 4,4-(dithiodicarbonothioyl)bis-
- 4,4'-(dithiodicarbonothioyl)dimorpholine