AZD-9574
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- CAS號:
- 2756333-39-6
- 英文名:
- 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl-
- 英文別名:
- AZD-9574;palacaparib;AZD-9574 ，E2147;AZD-9574, 10 mM in DMSO;6-Fluoro-5-(4-((5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl)piperazin-1-yl)-N-methylpicolinamide;6-fluoro-5-[4-[(5-fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]-1-piperazinyl]-N-methyl-2-pyridinecarboxamide;6-fluoro-5-[4-[(5-fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl]-N-methylpyridine-2-carboxamide;6-Fluoro-5-[4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydro-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methylpyridine-2-carboxamide;2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl-;6-fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide - [AC80836]
- 中文名:
- AZD-9574
- 中文別名:
- 化合物AZD-9574;AZD-9574 ,E2147;化合物AZD-9574,10 MM DMSO 溶液;6-氟-5-(4-((5-氟-2-甲基-3-氧代-3,4-二氫喹喔啉-6-基)甲基)哌嗪-1-基)-N-甲基吡啶-2-甲酰胺;6-氟-5-[4-[(5-氟-2-甲基-3-氧代-3,4-二氫-6-喹喔啉基)甲基]-1-哌嗪基]-N-甲基吡啶-2-甲酰胺;6-氟-5-[4-[(5-氟-3,4-二氫-2-甲基-3-氧代-6-喹喔啉基)甲基]-1-哌嗪基]-N-甲基-2-吡啶甲酰胺
- CBNumber:
- CB510752189
- 分子式:
- C21H22F2N6O2
- 分子量:
- 428.44
- MOL File:
- 2756333-39-6.mol
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AZD-9574化學性質
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密度:
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1.45±0.1 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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酸度系數(shù)(pKa):
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8.17±0.20(Predicted)
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形態(tài):
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Solid
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顏色:
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White to yellow
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InChI:
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InChI=1S/C21H22F2N6O2/c1-12-20(30)27-18-14(25-12)4-3-13(17(18)22)11-28-7-9-29(10-8-28)16-6-5-15(21(31)24-2)26-19(16)23/h3-6H,7-11H2,1-2H3,(H,24,31)(H,27,30)
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InChIKey:
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WXRCLFFPZXJCLS-UHFFFAOYSA-N
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SMILES:
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C1(C(NC)=O)=NC(F)=C(N2CCN(CC3C=CC4=C(C=3F)NC(=O)C(C)=N4)CC2)C=C1
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AZD-9574性質、用途與生產(chǎn)工藝
AZD-9574 是一種有效的，具有血腦屏障的通透性 PARP1 抑制劑，與 PARP2/3/5a/6 相比，對 PARP1 表現(xiàn)出 >8000 倍的選擇性。AZD-9574 在 SSB 位點選擇性抑制 PARP1。AZD-9574 是一種抗癌化合物，可用于 HRD+ 乳腺癌和晚期實體惡性腫瘤研究。
AZD-9574
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/06/05 | HY-145804 | AZD-9574 | 2756333-39-6 | 1 mg | 1350元 |
| 2026/06/05 | HY-145804 | AZD-9574
AZD-9574 | 2756333-39-6 | 5 mg | 3200元 |
2756333-39-6, AZD-9574 相關搜索:
- api
- 庫存
- 抑制劑
- 小分子抑制劑
- AZD-9574 ,E2147
- 化合物AZD-9574,10 MM DMSO 溶液
- 6-氟-5-(4-((5-氟-2-甲基-3-氧代-3,4-二氫喹喔啉-6-基)甲基)哌嗪-1-基)-N-甲基吡啶-2-甲酰胺
- 6-氟-5-[4-[(5-氟-2-甲基-3-氧代-3,4-二氫-6-喹喔啉基)甲基]-1-哌嗪基]-N-甲基吡啶-2-甲酰胺
- 6-氟-5-[4-[(5-氟-3,4-二氫-2-甲基-3-氧代-6-喹喔啉基)甲基]-1-哌嗪基]-N-甲基-2-吡啶甲酰胺
- 化合物AZD-9574
- 2756333-39-6
- 6-Fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl-2-pyridinecarboxamide (ACI)
- palacaparib
- AZD-9574
- 6-fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide - [AC80836]
- 6-fluoro-5-[4-[(5-fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl]-N-methylpyridine-2-carboxamide
- AZD-9574 ，E2147
- AZD-9574, 10 mM in DMSO
- 6-Fluoro-5-(4-((5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl)piperazin-1-yl)-N-methylpicolinamide
- 6-Fluoro-5-[4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydro-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methylpyridine-2-carboxamide
- 6-fluoro-5-[4-[(5-fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]-1-piperazinyl]-N-methyl-2-pyridinecarboxamide
- PPAR,Peroxisome proliferator-activated receptors,breast cancer,inhibit,AZD-9574,HRR,HRR-deficient cells,homologous recombination repair,HRD+,AZD 9574,Advanced Solid Malignancy,Inhibitor,aberrant DNA repair,AZD9574
- 2-Pyridinecarboxamide, 6-fluoro-5-[4-[(5-fluoro-3,4-dihydro-2-methyl-3-oxo-6-quinoxalinyl)methyl]-1-piperazinyl]-N-methyl-