RISARESTAT
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- CAS號(hào):
- 79714-31-1
- 英文名:
- CT 112
- 英文別名:
- Risarestat;RISARESTAT (CT-112);Risarestat, 10 mM in DMSO;CT 112 (reductase inhibitor);5-(3-Ethoxy-4-pentoxyphenyl)thiazolidine-2,4-dione;5-(3-Ethoxy-4-pentyloxyphenyl)-2,4-thiazolidinedione;5-[3-Ethoxy-4-(pentyloxy)phenyl]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-[3-ethoxy-4-(pentyloxy)phenyl]-
- 中文名:
- RISARESTAT
- 中文別名:
- 利沙司他;化合物 T16756;利沙司他,10 MM DMSO 溶液
- CBNumber:
- CB51334327
- 分子式:
- C16H21NO4S
- 分子量:
- 323.41
- MOL File:
- 79714-31-1.mol
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RISARESTAT化學(xué)性質(zhì)
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沸點(diǎn):
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485.9±45.0 °C(Predicted)
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密度:
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1.189±0.06 g/cm3(Predicted)
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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5.91±0.50(Predicted)
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顏色:
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White to light yellow
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RISARESTAT性質(zhì)、用途與生產(chǎn)工藝
Risarestat (CT-112)是一種醛糖還原酶抑制劑，開(kāi)發(fā)用于糖尿病并發(fā)癥的研究。
Risarestat inhibits the accumulation of dulcitol in a dose-dependent manner, except for the 1.0% solution which has an activity comparable to the 0.25% solution. Risarestat peaks in the corneal epithelium, stroma, endothelium and aqueous humor in 30 minutes following instillation, then gradually diminishes time-dependently over a period of 24 hours. Risarestat remains detectable in the lens up to 24 hours, with a peak concentration at 2 hours after instillation. The anterior surface area of superficial cells in the group treated with Risarestat is significantly decreases from a mean value of 881 to 728 microns
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. Corneal sensitivity significantly improves from 5.36 to 1.37 g/mm
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. Animals treated with Risarestat shows a significant increase in the mean blinkresponse compared to untreated galactose-fed rats and does not differ significantly from controls towards the completion of the 7 month study. Animals treated topically with Risarestat and untreated galactose-fed rats develop bilateral nuclear cataracts within 3 weeks.
RISARESTAT
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-16433 | Risarestat | 79714-31-1 | 1 mg | 1800元 |
| 2026/06/05 | HY-16433 | RISARESTAT
Risarestat | 79714-31-1 | 5mg | 4300元 |
79714-31-1, RISARESTAT 相關(guān)搜索:
- 抑制劑
- 利沙司他,10 MM DMSO 溶液
- 利沙司他
- 化合物 T16756
- 79714-31-1
- Risarestat, 10 mM in DMSO
- 2,4-Thiazolidinedione, 5-[3-ethoxy-4-(pentyloxy)phenyl]-
- RISARESTAT (CT-112)
- CT 112 (reductase inhibitor)
- Risarestat
- 5-[3-Ethoxy-4-(pentyloxy)phenyl]-2,4-thiazolidinedione
- 5-(3-Ethoxy-4-pentyloxyphenyl)-2,4-thiazolidinedione
- 5-(3-Ethoxy-4-pentoxyphenyl)thiazolidine-2,4-dione