B-赤霉醇
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- CAS號(hào):
- 42422-68-4
- 英文名:
- BETA-ZEARALANOL
- 英文別名:
- β-Zearalanol;taleranol;P-1560;β-Zeranol;BETAZERANOL;B-zearalanol;BETA-ZEARALANOL;Zearalanol, beta-;P-1560【pharmaceutical】;β-Zearalanol,β-Zeranol
- 中文名:
- B-赤霉醇
- 中文別名:
- B-赤霉醇;Β-赤霉醇;Β-玉米赤霉醇;玉米赤霉醇,Β-;乙腈中Β-玉米赤霉醇;Β-玉米赤霉醇標(biāo)準(zhǔn)品;化合物 T14548;BETA-玉米赤霉醇;-ZEARALANOL;Β-玉米赤霉醇檢測(cè)標(biāo)準(zhǔn)品
- CBNumber:
- CB5142969
- 分子式:
- C18H26O5
- 分子量:
- 322.4
- MOL File:
- 42422-68-4.mol
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B-赤霉醇化學(xué)性質(zhì)
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熔點(diǎn):
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134-137°C
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沸點(diǎn):
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576.0±50.0 °C(Predicted)
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密度:
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1.153±0.06 g/cm3(Predicted)
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閃點(diǎn):
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2℃
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儲(chǔ)存條件:
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2-8°C
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溶解度:
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Methanol: 10 mg/ml
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酸度系數(shù)(pKa):
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8.08±0.60(Predicted)
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形態(tài):
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A solid
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顏色:
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White to off-white
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BRN:
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4844761
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InChI:
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1S/C18H26O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h10-12,14,19-21H,2-9H2,1H3/t12-,14-/m0/s1
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InChIKey:
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DWTTZBARDOXEAM-JSGCOSHPSA-N
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SMILES:
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C[C@H]1CCC[C@@H](O)CCCCCc2cc(O)cc(O)c2C(=O)O1
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B-赤霉醇性質(zhì)、用途與生產(chǎn)工藝
Beta-Zearalanol 是由鐮刀菌屬 Fusarium 產(chǎn)生的一種霉菌毒素，可以在哺乳動(dòng)物生殖細(xì)胞中引起細(xì)胞凋亡 (apoptosis) 和氧化應(yīng)激反應(yīng)。 Beta-Zearalanol 是玉米赤霉烯酮（ZEA）的衍生物，可以與葡萄糖醛酸 (glucuronic acid) 結(jié)合。
βeta-Zearalenol (0-200 μM; 24 hours) inhibits BGC proliferation in a dose-dependent manner, with an IC
50
of 25 μM.
βeta-Zearalenol (0-100 μM; 72 hours) shows high toxic with an IC
50
of 15.2 μM in the HepG2 cells, synergistic effect of β-ZOL+ZEN or β-ZOL+α-ZOL with IC
50
values of 19.8 uM, 16.8 uM, respectively.
βeta-Zearalenol (0-10 μM; 72 hours) has the highest inhibition effect on the all three investigated cytokines: IL-8, IL-1β and TNF-α by comparation with ZEA or α-Zearalenol.
Cell Viability Assay
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Cell Line:
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HepG2 cells
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Concentration:
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0-100 μM
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Incubation Time:
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72 hours
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Result:
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Shown a dose-dependent reduction of viability of cells treated with Beta-Zearalanol.
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Cell Proliferation Assay
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Cell Line:
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BGC cells
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Concentration:
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0 μM, 5 μM, 10 μM, 15 μM, 25 μM, 50 μM, 100 μM, and 200 μM
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Incubation Time:
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24?hours
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Result:
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Inhibited cell proliferation in a dose-dependent manner.
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RT-PCR
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Cell Line:
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HepG2 cells
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Concentration:
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1 μM, 5 μM, 10 μM
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Incubation Time:
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72 hours
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Result:
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Had the higher cytotoxic effect in comparation with α-Zearalenol.
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B-赤霉醇
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-N6740 | B-赤霉醇
Beta-Zearalanol | 42422-68-4 | 5mg | 1600元 |
| 2026/06/05 | HY-N6740 | B-赤霉醇
Beta-Zearalanol | 42422-68-4 | 10 mM * 1 mLin DMSO | 1760元 |
42422-68-4, B-赤霉醇 相關(guān)搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Chiral Reagents
- Aromatics
- Heterpocycles
- 抑制劑
- 醫(yī)藥原料
- 霉菌毒素類
- 微生物代謝物
- 氘5-塔勒拉諾(氘5-β-玉米赤霉醇)
- 玉米赤霉醇,Β-
- 乙腈中BETA-玉米赤霉醇
- 乙腈中Β-玉米赤霉醇溶液標(biāo)準(zhǔn)物質(zhì)
- 乙腈中Β-玉米赤霉醇溶液
- 乙腈中Β-玉米赤霉醇
- Β-赤霉醇
- Β-玉米赤霉醇檢測(cè)標(biāo)準(zhǔn)品
- Β-玉米赤霉醇標(biāo)準(zhǔn)品
- Β-玉米赤霉醇-D5同位素
- 玉米赤霉醇(Β-玉米赤霉醇)
- 化合物 T14548
- BETA-玉米赤霉醇
- Β-玉米赤霉醇
- -ZEARALANOL
- B-赤霉醇
- 42422-68-4
- β-Zearalanol
- taleranol
- D5-Taleranol (D5-beta-Zearalanol)
- beta-Zearalanol 10 μg/mL in Acetonitrile
- B-Zearalanol in Acetonitrile
- β-Zearalanol in Acetonitrile
- Taleranol 10.0 μg/ml Acetonitrile
- 1H-2-Benzoxacyclotetradecin-1-one, 3,4,5,6,7,8,9,10,11,12-decahydro-7,14,16-trihydroxy-3-methyl-, (3S,7S)-
- β-Zeranol (1.0 mg/ml in Acetonitrile)
- β-Zearalanol,β-Zeranol
- Taleranol(β-zearalanol)
- Taleranol D4Q: What is
Taleranol D4 Q: What is the CAS Number of
Taleranol D4
- β-Zeranol
- beta-Zearalanol solution
- Taleranol (beta-Zearalanol)
- Taleranol (β-Zearalanol)
- (3S,7S)-3,4,5,6,7,8,9,10,11,12-Decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one solution
- Zearalanol, beta-
- Taleranol, beta-Zearanol, beta-Zeranol
- (7S,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(18),14,16-trien-13-one
- P-1560【pharmaceutical】
- P-1560
- (4S)-4β-Methyl-8β,16,18-trihydroxy-3-oxabicyclo[12.4.0]octadecane-1(14),15,17-triene-2-one
- (3S,7S)-3,4,5,6,7,8,9,10,11,12-Decahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one
- BETAZERANOL
- B-zearalanol
- 2,4-DIHYDROXY-6-[6BETA,10-DIHYDROXY-UNDECYL)BENZOIC ACID MICRO-LACTONE
- BETA-ZEARALANOL