N-叔丁氧碳?；?3,4-二氫吡啶-5-硼酸酯性質(zhì)、用途與生產(chǎn)工藝

生產(chǎn)方法 

149108-74-7

73183-34-3

1121057-77-9

步驟4. 將5-(((三氟甲基)磺?；?氧基)-3,4-二氫吡啶-1(2H)-羧酸叔丁酯（1.45g，4.38mmol）和聯(lián)硼酸頻那醇酯（1.223g，4.81mmol）溶于二惡烷（24mL）中。向此溶液中加入乙酸鉀（1.289g，13.13mmol）和PdCl2(dppf)-CH2Cl2加合物（0.107g，0.131mmol）。在氮?dú)獗Ｗo(hù)下，將反應(yīng)混合物吹掃5分鐘，隨后在80℃油浴中加熱過夜。反應(yīng)完成后，將混合物在乙酸乙酯和水之間分配。分離有機(jī)層，用鹽水洗滌，經(jīng)無水硫酸鈉干燥，過濾并濃縮。通過快速色譜法純化殘余物，使用0-30%乙酸乙酯/庚烷梯度洗脫，得到目標(biāo)產(chǎn)物5-硼酸頻哪醇酯基-3,4-二氫吡啶-1(2H)-羧酸叔丁酯，為高粘度液體（1.2g，收率89%）。LCMS（m/z）：254.1（MH+-tBu），保留時(shí)間1.21分鐘。

參考文獻(xiàn)：

[1] Patent: US9242996, 2016, B2. Location in patent: Page/Page column 385; 386; 388; 389

[2] Patent: WO2018/203256, 2018, A1. Location in patent: Page/Page column 36

[3] Patent: US2013/102601, 2013, A1. Location in patent: Paragraph 184

[4] Patent: US2013/102600, 2013, A1. Location in patent: Page/Page column 0169; 0171

[5] Patent: WO2015/48662, 2015, A2. Location in patent: Page/Page column 44-45

N-叔丁氧碳酰基-3,4-二氫吡啶-5-硼酸酯 上下游產(chǎn)品信息

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N-叔丁氧碳?；?3,4-二氫吡啶-5-硼酸酯 生產(chǎn)廠家

N-叔丁氧碳?；?3,4-二氫吡啶-5-硼酸酯 圖譜信息:

1121057-77-9, N-叔丁氧碳?；?3,4-二氫吡啶-5-硼酸酯 相關(guān)搜索:

• Organic boronic acid
• 叔-丁基 5-(四甲基-1,3,2-二噁硼戊環(huán)-2-基)-1,2,3,4-四氫吡啶-1-甲酸基酯
• 1-BOC-1,4,5,6-四氫吡啶-3-硼酸頻哪醇酯
• 5-硼酸頻哪醇酯基-3,4-二氫吡啶-1(2H)-羧酸叔丁酯
• 5-(4,4,5,5-四甲基-1,3,2-二氧雜環(huán)戊硼烷-2-基)-3,4-二氫吡啶-1(2H)-羧酸叔丁酯
• N-叔丁氧碳酰基-3,4-二氫吡啶-5-硼酸酯
• N-叔丁氧羰基-3,4-二氫吡啶-5-硼酸酯
• 1121057-77-9
• tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate - [T10684]
• ert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate
• 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
• tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1
• (1-(TERT-BUTOXYCARBONYL)-1,4,5,6-TETRAHYDROPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER
• tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dih
• 1(2H)-Pyridinecarboxylic acid, 3,4-dihydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester
• tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-t...
• tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2, 3,4-tetrahydropyridine-1-carboxylate
• 1-Boc-1,4,5,6-tetrahydropyridine-3-boronic Acid Pinacol Ester
• tert-butyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine-1-carboxylate
• N-boc-3,4-dihydropiperidine-5-boronic acid pinacol ester
• tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxyla