1-BOC-4-(4-溴苯甲酰)哌啶
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- CAS號(hào):
- 439811-37-7
- 英文名:
- 1-BOC-4-(4-BROMO-BENZOYL)-PIPERIDINE
- 英文別名:
- 1-BOC-4-(4-BROMO-BENZOYL)-PIPERIDINE;tert-butyl 4-(4-broMobenzoyl)piperidine-1-carboxylate;tert-butyl 4-[(4-broMophenyl)carbonyl]piperidine-1-carboxylate;4-(4-bromobenzoyl)piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-(4-bromobenzoyl)-, 1,1-dimethylethyl ester
- 中文名:
- 1-BOC-4-(4-溴苯甲酰)哌啶
- 中文別名:
- 1-BOC-4-(4-溴苯甲酰)哌啶;1-BOC-4-(4-溴苯甲?；?哌啶;叔丁基-丁基4-(4-溴苯甲酰基)哌啶-1-羧酸甲酯
- CBNumber:
- CB5413232
- 分子式:
- C17H22BrNO3
- 分子量:
- 368.27
- MOL File:
- 439811-37-7.mol
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1-BOC-4-(4-溴苯甲酰)哌啶化學(xué)性質(zhì)
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沸點(diǎn):
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452.3±40.0 °C(Predicted)
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密度:
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1.325±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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2-8°C
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酸度系數(shù)(pKa):
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-2.47±0.40(Predicted)
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外觀:
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Off-white to light yellow Solid
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1-BOC-4-(4-溴苯甲酰)哌啶性質(zhì)、用途與生產(chǎn)工藝
生產(chǎn)方法
步驟1. 合成4-(4-溴苯甲?；?-哌啶-1-羧酸叔丁酯。向250 mL圓底燒瓶中加入4-(4-溴苯甲?；?哌啶(5 g, 20 mmol)、四氫呋喃(30 mL)、水(30 mL)、碳酸鈉(10 g, 90 mmol)和二碳酸二叔丁酯(4.35 g, 20.0 mmol)。將反應(yīng)混合物在室溫下攪拌2小時(shí)，然后用乙酸乙酯和水進(jìn)行分配。水層用乙酸乙酯萃取兩次，合并有機(jī)相，用鹽水洗滌，干燥，過(guò)濾并濃縮，得到7.1 g(100%產(chǎn)率)的4-(4-溴苯甲酰基)-哌啶-1-羧酸叔丁酯。
參考文獻(xiàn)：
[1] Patent: WO2016/205590, 2016, A1. Location in patent: Paragraph 00596
[2] Patent: WO2013/147711, 2013, A1. Location in patent: Page/Page column 231
[3] Patent: US2014/371199, 2014, A1. Location in patent: Paragraph 0801
[4] Patent: US2005/54628, 2005, A1. Location in patent: Page/Page column 23-24
[5] Patent: US2005/49269, 2005, A1. Location in patent: Page/Page column 12; 21
1-BOC-4-(4-溴苯甲酰)哌啶
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
1-BOC-4-(4-溴苯甲酰)哌啶
生產(chǎn)廠家
439811-37-7, 1-BOC-4-(4-溴苯甲酰)哌啶 相關(guān)搜索:
- 砌塊
- 其它
- 叔丁基-丁基4-(4-溴苯甲?；?哌啶-1-羧酸甲酯
- 1-BOC-4-(4-溴苯甲?；?哌啶
- 1-BOC-4-(4-溴苯甲酰)哌啶
- 439811-37-7
- 4-(4-bromobenzoyl)piperidine-1-carboxylic acid tert-butyl ester
- 1-Piperidinecarboxylic acid, 4-(4-bromobenzoyl)-, 1,1-dimethylethyl ester
- tert-butyl 4-[(4-broMophenyl)carbonyl]piperidine-1-carboxylate
- tert-butyl 4-(4-broMobenzoyl)piperidine-1-carboxylate
- 1-BOC-4-(4-BROMO-BENZOYL)-PIPERIDINE