H3B-120
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- CAS號:
- 2194903-42-7
- 英文名:
- H3B-120
- 英文別名:
- H3B-120;H3B-120 ，S3244;H3B-120, 10 mM in DMSO;N1-Benzyl-N1-methyl-N4-(4-methylthiazol-2-yl)piperidine-1,4-dicarboxamide;1,4-Piperidinedicarboxamide, N1-methyl-N4-(4-methyl-2-thiazolyl)-N1-(phenylmethyl)-;H3B-120,Potassium Channel,KcsA,carbamoyl,inhibit,H3B120,H3B 120,Inhibitor,anti-cancer,phosphate,synthetase,CPS1,H-3B-120
- 中文名:
- H3B-120
- 中文別名:
- 化合物H3B-120;H3B-120 ,S3244;化合物H3B-120,10 MM DMSO 溶液;N1-芐基-N1-甲基-N4-(4-甲基噻唑-2-基)哌啶-1,4-二甲酰胺
- CBNumber:
- CB56193507
- 分子式:
- C19H24N4O2S
- 分子量:
- 372.48
- MOL File:
- 2194903-42-7.mol
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H3B-120化學性質
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密度:
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1.280±0.06 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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DMSO: 62.5 mg/mL (167.79 mM)
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酸度系數(shù)(pKa):
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8.28±0.70(Predicted)
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形態(tài):
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Solid
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顏色:
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Off-white to yellow
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InChI:
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1S/C19H24N4O2S/c1-14-13-26-18(20-14)21-17(24)16-8-10-23(11-9-16)19(25)22(2)12-15-6-4-3-5-7-15/h3-7,13,16H,8-12H2,1-2H3,(H,20,21,24)
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InChIKey:
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ZEVOZXRSCSSPAO-UHFFFAOYSA-N
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SMILES:
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O=C(C1CCN(CC1)C(N(C)CC2=CC=CC=C2)=O)NC3=NC(C)=CS3
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H3B-120性質、用途與生產工藝
H3B-120 是一種競爭性的、選擇性的 carbamoyl phosphate synthetase 1 (CPS1) 變構抑制劑，其IC50值為1.5 μM，其Ki值為1.4 μM。H3B-120 表現(xiàn)出抗腫瘤活性。
| Target | Value |
CPS1
(Cell-free assay)
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1.4 μM(Ki)
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CPS1
(Cell-free assay)
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1.5 μM
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H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase).
H3B-120 achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains.
H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays.
The half-life of H3B-120 is only 40 min.
H3B-120
上下游產品信息
上游原料
下游產品
| 更新日期 | 產品編號 | 產品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/07/06 | S3244 | H3B-120 | 2194903-42-7 | 10mM (1mL in DMSO) | 2841.93元 |
| 2026/07/06 | S3244 | N1-芐基-N1-甲基-N4-(4-甲基噻唑-2-基)哌啶-1,4-二甲酰胺
H3B-120 | 2194903-42-7 | 5mg | 3170.13元 |
2194903-42-7, H3B-120 相關搜索:
- 抑制劑
- 藥靶配體
- H3B-120 ,S3244
- 化合物H3B-120,10 MM DMSO 溶液
- 化合物H3B-120
- N1-芐基-N1-甲基-N4-(4-甲基噻唑-2-基)哌啶-1,4-二甲酰胺
- 2194903-42-7
- H3B-120 ，S3244
- H3B-120, 10 mM in DMSO
- 1,4-Piperidinedicarboxamide, N1-methyl-N4-(4-methyl-2-thiazolyl)-N1-(phenylmethyl)-
- H3B-120,Potassium Channel,KcsA,carbamoyl,inhibit,H3B120,H3B 120,Inhibitor,anti-cancer,phosphate,synthetase,CPS1,H-3B-120
- N1-Benzyl-N1-methyl-N4-(4-methylthiazol-2-yl)piperidine-1,4-dicarboxamide
- H3B-120