Kymera Therapeutics' CDK2 degrader PROTAC
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- CAS號:
- 3030271-16-7
- 英文名:
- 2,6-Piperidinedione, 3-[4-[4-[[4-[[4-[[6-chloro-7,8-dihydro-8-(1-methylethyl)-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]-3-methylphenyl]sulfonyl][1,4′-bipiperidin]-1′-yl]methyl]-1-piperidinyl]-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl]-
- 英文別名:
- 3-(4-(4-((4-((4-((6-chloro-8-isopropyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-3-methylphenyl)sulfonyl)-[1,4'-bipiperidin]-1'-yl)methyl)piperidin-1-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[;3-(4-(4-((4-((4-((6-chloro-8-isopropyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-3-methylphenyl)sulfonyl)-[1,4'-bipiperidin]-1'-yl)methyl)piperidin-1-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione;2,6-Piperidinedione, 3-[4-[4-[[4-[[4-[[6-chloro-7,8-dihydro-8-(1-methylethyl)-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]-3-methylphenyl]sulfonyl][1,4′-bipiperidin]-1′-yl]methyl]-1-piperidinyl]-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl]-
- 中文名:
- Kymera Therapeutics' CDK2 degrader PROTAC
- 中文別名:
- CBNumber:
- CB614685167
- 分子式:
- C46H57ClN10O6S
- 分子量:
- 913.53
- MOL File:
- 3030271-16-7.mol
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Kymera Therapeutics' CDK2 degrader PROTAC化學(xué)性質(zhì)
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密度:
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1.45±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
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酸度系數(shù)(pKa):
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11.11±0.40(predicted)
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形態(tài):
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Solid
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顏色:
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White to off-white
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Kymera Therapeutics' CDK2 degrader PROTAC性質(zhì)、用途與生產(chǎn)工藝
CDK2 degrader 2 是一種 PROTAC 類的 CDK2 降解劑。CDK2 結(jié)合部分 (CBM) 與 CDK2 蛋白結(jié)合，隨后發(fā)生泛素化，從而通過泛素-蛋白酶體途徑 (UPP) 降解 CDK2。CDK2 degrader 2 可以引起 MKN1 細胞中的 CDK2 降解，DC50 值小于 100 nM，平均 Dmax 值大于 75 % (Red: CBM; Blue: DIM; Black: linker)。
Kymera Therapeutics' CDK2 degrader PROTAC
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
Kymera Therapeutics' CDK2 degrader PROTAC
生產(chǎn)廠家
| 供應(yīng)商 | 聯(lián)系電話 | 電子郵件 | 國家 | 產(chǎn)品數(shù) | 優(yōu)勢度 |
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上海藥砌源生物科技有限公司
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021-15026428026 15026428026
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ChemOrigin@126.com
| 中國 |
1112
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58
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3030271-16-7, Kymera Therapeutics' CDK2 degrader PROTAC 相關(guān)搜索:
- 抗腫瘤小分子
- 3030271-16-7
- 3-(4-(4-((4-((4-((6-chloro-8-isopropyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-3-methylphenyl)sulfonyl)-[1,4'-bipiperidin]-1'-yl)methyl)piperidin-1-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione
- 3-(4-(4-((4-((4-((6-chloro-8-isopropyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-3-methylphenyl)sulfonyl)-[1,4'-bipiperidin]-1'-yl)methyl)piperidin-1-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[
- 2,6-Piperidinedione, 3-[4-[4-[[4-[[4-[[6-chloro-7,8-dihydro-8-(1-methylethyl)-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]-3-methylphenyl]sulfonyl][1,4′-bipiperidin]-1′-yl]methyl]-1-piperidinyl]-2,3-dihydro-3-methyl-2-oxo-1H-benzimidazol-1-yl]-