(±)-TRANS-ACPD
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- CAS號:
- 67684-64-4
- 英文名:
- (+/-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID
- 英文別名:
- TRANS-ACPD;Trans-(±)-ACP;TRANS-(±)-ACPD;(±)-trans-ACPD;TRANS-(+/-)-ACPD;(+/-)-TRANS-ACPD;trans-ACPD, 10 mM in DMSO;trans-(±)-ACPD monohydrate;trans-(±)-ACPD monohydrate;TRANS(+-)-ACPD EXCITATORY AMINO ACID
- 中文名:
- (±)-TRANS-ACPD
- 中文別名:
- 化合物(±)-TRANS-ACPD;TRANS-1-氨基環(huán)戊烷-1,3-二羧酸;化合物(±)-TRANS-ACPD,10 MM DMSO 溶液
- CBNumber:
- CB6198448
- 分子式:
- C7H11NO4
- 分子量:
- 173.17
- MOL File:
- 67684-64-4.mol
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(±)-TRANS-ACPD化學性質(zhì)
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沸點:
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352.7±42.0 °C(Predicted)
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密度:
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1.452±0.06 g/cm3(Predicted)
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儲存條件:
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Keep in dark place,Inert atmosphere,2-8°C
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溶解度:
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H2O: soluble1mg/mL
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形態(tài):
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solid
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酸度系數(shù)(pKa):
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2.11±0.40(Predicted)
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顏色:
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white
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水溶解性:
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Soluble to 5 mM in water with gentle warming and to 50 mM in 1eq. NaOH
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InChI:
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1S/C7H11NO4.H2O/c8-7(6(11)12)2-1-4(3-7)5(9)10;/h4H,1-3,8H2,(H,9,10)(H,11,12);1H2/t4-,7+;/m1./s1
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InChIKey:
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AZRMVYVZWAKHMR-RERZVJIGSA-N
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SMILES:
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O.N[C@]1(CC[C@H](C1)C(O)=O)C(O)=O
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(±)-TRANS-ACPD性質(zhì)、用途與生產(chǎn)工藝
trans-ACPD 是一種代謝型受體激動劑，促進鈣離子活動及產(chǎn)生內(nèi)向電流。
Excitatory amino acid (EAA) analogues activate receptors that are coupled to the increased hydrolysis of phosphoinositides (PIs). In these studies, hippocampal slices are prepared from neonatal rats (6-11 days old) to characterize the effects of EAA analogues on these receptors. The concentrations of trans-ACPD required to evoke half-maximal stimulation (EC
50
value) is 51 μM. DL-2-Amino-3-phosphonopropionate (DL-AP3) is also equipotent as an inhibitor of PI hydrolysis stimulated by ibotenate, quisqualate, and trans-ACPD (IC
50
values are 480-850 μM).
Intrathecal injection of NMDA, kainate, and trans-ACPD, TNF-α, or IL-1β causes significant (p<0.001) biting behaviour in mice compared to animals injected intrathecally with saline. In all groups, systemic pre-treatment with GM (100 mg/kg, i.p.) significantly (p<0.001) reduces the biting behaviour compared to mice treated with saline (10 mL/kg, i.p.). The greatest effect of GM is observed on the pro-inflammatory cytokines and NMDA, with the following inhibition percentages: TNF-α (92±7%), IL-1β (91±5%), NMDA (69±1%), and trans-ACPD (71±12%). By contrast, at the same dose, GM has no significant effect on the kainate-mediated biting response.
(±)-TRANS-ACPD
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2026/06/05 | HY-19434 | (±)-TRANS-ACPD
trans-ACPD | 67684-64-4 | 1 mg | 365元 |
| 2026/06/05 | HY-19434 | (±)-TRANS-ACPD
trans-ACPD | 67684-64-4 | 5mg | 830元 |
(±)-TRANS-ACPD
生產(chǎn)廠家
67684-64-4, (±)-TRANS-ACPD 相關(guān)搜索:
- 抑制劑
- C7H11NO4H2O
- 化合物(±)-TRANS-ACPD,10 MM DMSO 溶液
- TRANS-1-氨基環(huán)戊烷-1,3-二羧酸
- 化合物(±)-TRANS-ACPD
- 67684-64-4
- (±)-1-Aminocyclopentanl-trans-1,3-Dicarboxylic acid
- (±)-trans-ACPD
- trans-(±)-ACPD monohydrate
- trans-ACPD, 10 mM in DMSO
- trans-ACPD,transACPD,Metabotropic glutamate receptors,trans ACPD,mGluR,Inhibitor,inhibit
- trans-1-Aminocyclopentane-1,3-dicarboxylic acid
- 1,3-Cyclopentanedicarboxylic acid, 1-amino-, (1R,3S)-rel-
- Trans-(±)-ACP
- TRANS-(±)-ACPD
- (+/-)-1-Aminocyclopentanl-trans-1,3-Dicarboxylic acid
- trans-(±)-ACPD monohydrate
- trans-(±)-1-Amino-1,3-cyclopentanedicarboxylic acid monohydrate
- TRANS(+-)-ACPD EXCITATORY AMINO ACID
- TRANS-ACPD
- TRANS-(+/-)-ACPD
- (+/-)-TRANS-ACPD
- TRANS-(+/-)-1-AMINO-1,3-CYCLOPENTANEDICARBOXYLIC ACID
- (+/-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID