3-(4-broMophenyl)-1-Morpholinopropan-1-one synthesis
- Product Name:3-(4-broMophenyl)-1-Morpholinopropan-1-one
- CAS Number:607744-33-2
- Molecular formula:C13H16BrNO2
- Molecular Weight:298.18
Yield:607744-33-2 93%
Reaction Conditions:
in dichloromethane at 0 - 5; for 1 h;
Steps:
62.5 Step 5: Synthesis of 3-(4-bromophenyl)-l-morpholinopropan-l-one
To a solution of morpholine (11 g, 126.44 mmol, 2.01 equiv) in dichloromethane (60 mL) 0~5°C was added a solution of 3-(4-bromophenyl)propanoyl chloride (15.5 g, 63.01 mmol, 1.00 equiv) in dichloromethane (30 mL) dropwise with stirring. The resulting solution was stirred at 0~5°C for 1 h. The reaction mixture was warmed to room temperature. The resulting solution was diluted with 40 mL of water. The mixture was extracted with dichloromethane 2x100 mL. The combined organic layers was washed with 3x50 mL of brine, dried over anhydrous sodium sulfate and concentrated under vacuum to give 17.4 g (93%) of 3-(4-bromophenyl)-l- morpholinopropan-l-one as a white solid.
References:
WO2013/155338,2013,A2 Location in patent:Page/Page column 176-177
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