2-(2,4-Dihydroxyphenyl)-3-(3-methyl-2-butenyl)-5-hydroxy-8,8-dimethyl-4H,8H-benzo[1,2-b:5,4-b']dipyran-4-one
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- CAS號(hào):
- 19275-49-1
- 英文名:
- 2-(2,4-Dihydroxyphenyl)-3-(3-methyl-2-butenyl)-5-hydroxy-8,8-dimethyl-4H,8H-benzo[1,2-b:5,4-b']dipyran-4-one
- 英文別名:
- Cudraflavone B;8-(2,4-Dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one;2-(2,4-Dihydroxyphenyl)-3-(3-methyl-2-butenyl)-5-hydroxy-8,8-dimethyl-4H,8H-benzo[1,2-b:5,4-b']dipyran-4-one;2H,6H-Benzo[1,2-b:5,4-b']dipyran-6-one, 8-(2,4-dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-
- 中文名:
- 中文別名:
- CBNumber:
- CB62269278
- 分子式:
- C25H24O6
- 分子量:
- 420.45
- MOL File:
- 19275-49-1.mol
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2-(2,4-Dihydroxyphenyl)-3-(3-methyl-2-butenyl)-5-hydroxy-8,8-dimethyl-4H,8H-benzo[1,2-b:5,4-b']dipyran-4-one化學(xué)性質(zhì)
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熔點(diǎn):
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232-235 °C
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沸點(diǎn):
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638.5±55.0 °C(Predicted)
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密度:
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1.303±0.06 g/cm3(Predicted)
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酸度系數(shù)(pKa):
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6.35±0.60(Predicted)
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2-(2,4-Dihydroxyphenyl)-3-(3-methyl-2-butenyl)-5-hydroxy-8,8-dimethyl-4H,8H-benzo[1,2-b:5,4-b']dipyran-4-one性質(zhì)、用途與生產(chǎn)工藝
Cudraflavone B 是一種異戊二烯化類黃酮，具有抗炎和抗癌特性。Cudraflavone B 也是 COX-1 和 COX-2 的雙重抑制劑。Cudraflavone B 阻斷巨噬細(xì)胞中 核因子 κB (NF-κB) 從細(xì)胞質(zhì)到細(xì)胞核的易位。由此，Cudraflavone B 也抑制腫瘤壞死因子 α (TNFα) 的基因表達(dá)和分泌。Cudraflavone B 還觸發(fā)線粒體凋亡通路，激活 NF-κB、MAPK p38 和 ERK，并誘導(dǎo) SIRT1 的表達(dá)。由此，Cudraflavone B 抑制人口腔鱗狀細(xì)胞癌細(xì)胞的生長(zhǎng)。
2-(2,4-Dihydroxyphenyl)-3-(3-methyl-2-butenyl)-5-hydroxy-8,8-dimethyl-4H,8H-benzo[1,2-b:5,4-b']dipyran-4-one
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
2-(2,4-Dihydroxyphenyl)-3-(3-methyl-2-butenyl)-5-hydroxy-8,8-dimethyl-4H,8H-benzo[1,2-b:5,4-b']dipyran-4-one
生產(chǎn)廠家
19275-49-1, 2-(2,4-Dihydroxyphenyl)-3-(3-methyl-2-butenyl)-5-hydroxy-8,8-dimethyl-4H,8H-benzo[1,2-b:5,4-b']dipyran-4-one 相關(guān)搜索:
- 標(biāo)準(zhǔn)品
- 19275-49-1
- 2H,6H-Benzo[1,2-b:5,4-b']dipyran-6-one, 8-(2,4-dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-
- Cudraflavone B
- 8-(2,4-Dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one
- 2-(2,4-Dihydroxyphenyl)-3-(3-methyl-2-butenyl)-5-hydroxy-8,8-dimethyl-4H,8H-benzo[1,2-b:5,4-b']dipyran-4-one