1-(三異丙基硅烷基)吡咯-3-硼酸
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- CAS號(hào):
- 138900-55-7
- 英文名:
- 1-(Triisopropylsilyl)pyrrole-3-boronic acid
- 英文別名:
- AKOS BRN-0345;RARECHEM AH PB 0020;1-Tris(isopropylsilyl)-1H...;Triisopropylsilyl pyrrole-3- boronic acid;1-(TRIISOPROPYLSILYL)PYRROLE-3-BORONIC ACID;1-(TRIISOPROPYLSILYL)-1H-PYRROLE-3-BORONIC ACID;1-(triisopropylsilyl)-1H-pyrrol-3-ylboronic acid;1-Tris(isopropylsilyl)-1H-pyrrole-3-boronic acid;[1-tri(propan-2-yl)silyl-3-pyrrolyl]boronic acid;1-(Triisopropylsilyl)pyrrole-3-boronic acid, 90+%
- 中文名:
- 1-(三異丙基硅烷基)吡咯-3-硼酸
- 中文別名:
- 1-三異丙硅基吡咯-3-硼酸;1-(三異丙基硅基)吡咯-3-硼酸;1-(三異丙基硅烷基)吡咯-3-硼酸;1-(三異丙基硅烷基)吡咯-3-硼酸 1G;1-(三異丙基硅烷基)-1H-吡咯-3-硼酸;1-(三異丙基甲硅烷基)-1H-吡咯-3-硼酸;(1-(三異丙基甲硅烷基)-1H-吡咯-3-基)硼酸;硼酸, B-[1-[三(異丙基)硅烷基]-1H-吡咯-3-基]-
- CBNumber:
- CB6306410
- 分子式:
- C13H26BNO2Si
- 分子量:
- 267.25
- MOL File:
- 138900-55-7.mol
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1-(三異丙基硅烷基)吡咯-3-硼酸化學(xué)性質(zhì)
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沸點(diǎn):
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337.9±34.0 °C(Predicted)
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密度:
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0.96±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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Inert atmosphere,Store in freezer, under -20°C
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形態(tài):
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solid
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酸度系數(shù)(pKa):
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9.41±0.10(Predicted)
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顏色:
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White
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InChI:
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1S/C13H26BNO2Si/c1-10(2)18(11(3)4,12(5)6)15-8-7-13(9-15)14(16)17/h7-12,16-17H,1-6H3
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InChIKey:
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HUBVAOMVEMGRFA-UHFFFAOYSA-N
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SMILES:
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CC(C)[Si](C(C)C)(C(C)C)n1ccc(c1)B(O)O
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CAS 數(shù)據(jù)庫(kù):
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138900-55-7(CAS DataBase Reference)
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1-(三異丙基硅烷基)吡咯-3-硼酸性質(zhì)、用途與生產(chǎn)工藝
1-(三異丙基硅烷基)吡咯-3-硼酸主要用于有機(jī)試劑。
生產(chǎn)方法
步驟92b：1-(三異丙基硅基)吡咯-3-硼酸（化合物0602-197）的合成
在氮?dú)獗Ｗo(hù)下，向攪拌中的3-溴-1-(三異丙基甲硅烷基)吡咯（0601-197，1g，3.31mmol）的無(wú)水THF（20mL）溶液中，于-78℃緩慢加入正丁基鋰的THF溶液（2.5M，1.58mL，3.96mmol）。保持該溫度，繼續(xù)攪拌30分鐘。隨后，向反應(yīng)混合物中逐滴加入硼酸三甲酯（687mg，6.6mmol）。反應(yīng)混合物逐漸升溫至室溫，并繼續(xù)攪拌1小時(shí)。反應(yīng)完成后，將混合物用200mL水稀釋?zhuān)⒂?00mL乙酸乙酯萃取。有機(jī)相依次用100mL水（兩次）和100mL鹽水洗滌，無(wú)水硫酸鈉干燥。減壓濃縮后，得到粗產(chǎn)物0602-197（280mg，收率32%），為油狀物，直接用于下一步反應(yīng)，無(wú)需進(jìn)一步純化。LCMS檢測(cè)顯示分子離子峰為268 [M + 1]+。
參考文獻(xiàn)：
[1] Tetrahedron, 2004, vol. 60, # 34, p. 7141 - 7146
[2] Patent: WO2010/62559, 2010, A1. Location in patent: Page/Page column 105; 106
[3] Patent: US2013/102595, 2013, A1. Location in patent: Paragraph 0608
1-(三異丙基硅烷基)吡咯-3-硼酸
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
1-(三異丙基硅烷基)吡咯-3-硼酸
生產(chǎn)廠家
138900-55-7, 1-(三異丙基硅烷基)吡咯-3-硼酸 相關(guān)搜索:
- Pyrrole
- Organoborons
- Boronic acid
- Boronic acids
- C13H26BNO2Si
- 1-(三異丙基硅基)吡咯-3-硼酸
- 1-(三異丙基甲硅烷基)-1H-吡咯-3-硼酸
- (1-(三異丙基甲硅烷基)-1H-吡咯-3-基)硼酸
- 1-三異丙硅基吡咯-3-硼酸
- 1-(三異丙基硅烷基)吡咯-3-硼酸
- 1-(三異丙基硅烷基)-1H-吡咯-3-硼酸
- 硼酸, B-[1-[三(異丙基)硅烷基]-1H-吡咯-3-基]-
- 1-(三異丙基硅烷基)吡咯-3-硼酸 1G
- 138900-55-7
- 1-(Triisopropylsilyl)pyrrole-3-boronic acid - [TN210]
- B-[1-[Tris(1-methylethyl)silyl]-1H-pyrrol-3-yl]boronic acid
- [1-tri(propan-2-yl)silyl-3-pyrrolyl]boronic acid
- 1-(Triisopropylsilyl)pyrrole-3-boronic acid, 90+%
- Boronic acid, B-[1-[tris(1-Methylethyl)silyl]-1H-pyrrol-3-yl]-
- 1-(triisopropylsilyl)-1H-pyrrol-3-yl-3-ylboronic acid
- {1-[tris(propan-2-yl)silyl]-1H-pyrrol-3-yl}boronic acid
- 3-Borono-1-[tris(isopropyl)silyl]-1H-pyrrole, (3-Borono-1H-pyrrol-1-yl)[tris(prop-2-yl)]silane, (3-Borono-1H-pyrol-1-yl)[tris(isopropyl)]silane
- 1-Tris(isopropylsilyl)-1H...
- 1-(triisopropylsilyl)-1H-pyrrol-3-yl-3-boronic acid
- Triisopropylsilyl pyrrole-3- boronic acid
- 1-(triisopropylsilyl)-1H-pyrrol-3-ylboronic acid
- 1-Tris(isopropylsilyl)-1H-pyrrole-3-boronic acid
- 1-(TRIISOPROPYLSILYL)-1H-PYRROLE-3-BORONIC ACID
- 1-(TRIISOPROPYLSILYL)PYRROLE-3-BORONIC ACID
- AKOS BRN-0345
- RARECHEM AH PB 0020