GSK-626616
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- CAS號:
- 1025821-33-3
- 英文名:
- GSK-626616
- 英文別名:
- GSK-626616;GSK 626616 - Bio-X ?;GSK-626616, 10 mM in DMSO;(Z)-2-((2,6-Dichlorophenyl)amino)-5-(quinoxalin-6-ylmethylene)thiazol-4(5H)-one;(5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone;4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-;GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase
- 中文名:
- GSK-626616
- 中文別名:
- 化合物GSK-626616;GSK 626616,DYRK抑制劑;1025821-33-3;GSK 626616;化合物GSK-626616,10 MM DMSO 溶液;(Z)-2-((2,6-二氯苯基)氨基)-5-(喹喔啉-6-基亞甲基)噻唑-4(5H)-酮
- CBNumber:
- CB63303333
- 分子式:
- C18H10Cl2N4OS
- 分子量:
- 401.27
- MOL File:
- 1025821-33-3.mol
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GSK-626616化學(xué)性質(zhì)
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熔點(diǎn):
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281 - 282oC
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沸點(diǎn):
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574.8±60.0 °C(Predicted)
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密度:
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1.55±0.1 g/cm3(Predicted)
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儲存條件:
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Refrigerator, under inert atmosphere
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溶解度:
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Chloroform (Slightly, Heated), Methanol (Slightly)
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形態(tài):
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Solid
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酸度系數(shù)(pKa):
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-0.94±0.20(Predicted)
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顏色:
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Pale Yellow to Light Yellow
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InChI:
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1S/C18H10Cl2N4OS/c19-11-2-1-3-12(20)16(11)23-18-24-17(25)15(26-18)9-10-4-5-13-14(8-10)22-7-6-21-13/h1-9H,(H,23,24,25)/b15-9-
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InChIKey:
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RJPNRXFBYZVRIB-DHDCSXOGSA-N
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SMILES:
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ClC(C=CC=C1Cl)=C1NC2=NC(/C(S2)=C/C3=CC4=C(N=CC=N4)C=C3)=O
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GSK-626616性質(zhì)、用途與生產(chǎn)工藝
GSK-626616 是一種有效的口服生物可利用的 DYRK3 抑制劑，IC50為 0.7 nM。GSK-626616 以相似的效力抑制 DYRK 家族的其他成員 (例如，DYRK1A和DYRK2)，GSK-626616 可用于貧血研究。
GSK-626616 abolishes the phosphorylation of S6K1 at Thr389 in nonstimulated HeLa cells. GSK-626616 reduces the phosphorylation of S6K1 at Thr389 in EGF- and insulin-stimulated HeLa cells, showing that mTORC1 activity is impaired.
GSK-626616 (serum-deprived HeLa cells) reduces EGF-induced phosphorylation of PRAS40 at Thr246. Binding of PRAS40 to mTORC1 is enhanced by GSK-626616.
GSK-626616
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-105309 | GSK-626616 | 1025821-33-3 | 1 mg | 457元 |
| 2026/06/05 | HY-105309 | GSK-626616
GSK-626616 | 1025821-33-3 | 5mg | 1100元 |
1025821-33-3, GSK-626616 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- 1025821-33-3;GSK 626616
- 化合物GSK-626616,10 MM DMSO 溶液
- (Z)-2-((2,6-二氯苯基)氨基)-5-(喹喔啉-6-基亞甲基)噻唑-4(5H)-酮
- GSK 626616,DYRK抑制劑
- 化合物GSK-626616
- 1025821-33-3
- GSK 626616 - Bio-X ?
- GSK-626616, 10 mM in DMSO
- (Z)-2-((2,6-Dichlorophenyl)amino)-5-(quinoxalin-6-ylmethylene)thiazol-4(5H)-one
- GSK 626616,DYRK,Inhibitor,Dual specificity tyrosine regulated kinase,GSK-626616,GSK626616,inhibit,Dual specificity tyrosine phosphorylation regulated kinase
- 4(5H)-Thiazolone, 2-[(2,6-dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-, (5Z)-
- (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylene)-4(5H)-thiazolone
- GSK-626616