APALCILLIN性質(zhì)、用途與生產(chǎn)工藝

概述

Apalcillin (PC-904) 與 Ro 48-1220（一種青霉砜β-內(nèi)酰胺酶抑制劑）聯(lián)合使用，對革蘭氏陰性需氧和厭氧細(xì)菌（不包括產(chǎn)酸克雷伯菌）表現(xiàn)出廣譜活性。它對產(chǎn)生 β-內(nèi)酰胺酶的卡他莫拉菌、流感嗜血桿菌和淋病奈瑟菌表現(xiàn)出強(qiáng)效活性，有效 MIC（11 μg/mL）。該組合還可在低 MIC（0.25 至 4 μg/mL）下抑制銅綠假單胞菌、嗜麥芽窄食單胞菌和不動桿菌。然而，其對苯唑西林耐藥葡萄球菌和某些革蘭氏陽性菌的療效有限。Apalcillin/Ro 48-1220 對某些產(chǎn)超廣譜 β-內(nèi)酰胺酶的大腸桿菌的療效與哌拉西林/他唑巴坦相當(dāng)，但對 SHV 型 β-內(nèi)酰胺酶的療效較差。

APALCILLIN 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

APALCILLIN 生產(chǎn)廠家

 

63469-19-2, APALCILLIN 相關(guān)搜索:

• 抑制劑
• C25H23N5O6S
• 化合物 Apalcillin
• 63469-19-2
• APALCILLIN USP/EP/BP
• 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-[[(4-hydroxy-1,5-naphthyridin-3-yl)carbonyl]amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
• Lumota
• Apalcilline
• Apalcilina [inn-spanish]
• Apalcilina
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2R)-(((4-hydroxy-1,5-naphthyridin-3-yl)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
• 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((((4-hydroxy-1,5-naphthyridin-3-yl)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2-alpha,5-alpha,6-beta(S*)))-
• (6R)-6-((R)-2-(4-Hydroxy-1,5-naphthyridin-3-carboxamido)-2-phenylacetamido)penicillansaeure
• (2S,5R,6R)-6-((R)-2-(4-Hydroxy-1,5-naphthyridin-3-carboxamido)-2-phenylacetamido)-3,3-dimethyl-7-oxo-5-thia-1-azabicyclo(3.2.0)heptan-2-carboxylic acid
• (2S,5R,6R)-6-((R)-2-(4-Hydroxy-1,5-naphthyridin-3-carboxamido)-2-phenylacetamido)-3,3-dimethyl-7-oxo-5-thia-1-azabicyclo(3.2.0)heptan-2-carbonsaeure
• 6α-[(R)-2-[(4-Hydroxy-1,5-naphthyridin-3-yl)carbonylamino]-2-phenylacetylamino]penicillanic acid
• (2S,5R,6R)-6α-[[(R)-(4-Hydroxypyrido[3,2-b]pyridin-3-ylcarbonylamino)phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid
• APALCILLIN
• 5-alpha,6-beta(s*)))-ph
• 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,6-(((((4-hydroxy-1,5-napht
• 3-dimethyl-7-oxo-hyridin-3-yl)carbonyl)amino)phenylacetyl)amino)-(2s-(2-al