EHNA
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- CAS號:
- 58337-38-5
- 英文名:
- erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
- 英文別名:
- EHNA hydrochloride[E114];rac erythro-9-(2-Hydroxy-3-nonyl)adenine Hydrochloride Salt;erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride;erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
- 中文名:
- EHNA
- 中文別名:
- 化合物 T11168;外消旋-9-(2-羥基-3-壬基)腺嘌呤鹽酸鹽;EHNA hydrochloride[E114]
- CBNumber:
- CB72130522
- 分子式:
- C14H24ClN5O
- 分子量:
- 313.82626
- MOL File:
- 58337-38-5.mol
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EHNA化學性質(zhì)
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熔點:
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163-180°C
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儲存條件:
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2-8°C
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溶解度:
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DMSO: >10mg/mL
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形態(tài):
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Solid
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顏色:
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Off-White to Beige
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InChI:
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1S/C14H23N5O.ClH/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19;/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17);1H/t10-,11+;/m0./s1
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InChIKey:
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VVDXNJRUNJMYOZ-VZXYPILPSA-N
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SMILES:
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Cl[H].CCCCCC[C@H]([C@H](C)O)n1cnc2c(N)ncnc12
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EHNA性質(zhì)、用途與生產(chǎn)工藝
EHNA hydrochloride 是一個強有力的和選擇性的環(huán)核苷酸磷酸二酯酶 2 (PDE2) (IC50=4 μM) 和腺苷脫氨酶 (ADA) 的雙重抑制劑。EHNA hydrochloride 濃度依耐性抑制 cGMP 刺激的 PDE2 的活性，IC50 值分別為 0.8 μM (人類) 和 2 μM (豬心肌)，但是對沒有刺激的 PDE2 抑制力較小。EHNA hydrochloride 在調(diào)節(jié)多種藥理反應(yīng)中發(fā)揮作用，包括抗病毒、抗腫瘤和抗心律失常作用。
EHNA completely ablates the ability of cyclic GMP to activate PDE2 activity, whilst having a much smaller inhibitory effect on the unstimulated PDE2 activity.EHNA exhibits normal Michaelian kinetics of inhibition for the cyclic GMP-stimulated PDE2 activity with Hill plots near unity.EHNA prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts.
EHNA
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/06/05 | HY-103160A | EHNA
EHNA hydrochloride | 58337-38-5 | 2 mg | 1600元 |
| 2026/06/05 | HY-103160A | EHNA
EHNA hydrochloride | 58337-38-5 | 5 mg | 2500元 |
58337-38-5, EHNA 相關(guān)搜索:
- Inhibitors, Nucleotides, Bases & Related Reagents
- Selective inhibitor of cGMP-stimulated phosphodiesterase.
- 抑制劑
- C14H23N5OClH
- C14H23N5OXHCl
- EHNA hydrochloride[E114]
- 化合物 T11168
- 外消旋-9-(2-羥基-3-壬基)腺嘌呤鹽酸鹽
- 58337-38-5
- EHNA hydrochloride[E114]
- rac erythro-9-(2-Hydroxy-3-nonyl)adenine Hydrochloride Salt
- erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
- erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride