在肌肉細(xì)胞中,740Y-P可刺激促有絲分裂反應(yīng),這一作用具有特異性,并不是細(xì)胞透性SH2結(jié)合肽段的普遍特征。740Y-P能通過PI3K-Akt級(jí)聯(lián)反應(yīng)促進(jìn)神經(jīng)元細(xì)胞的生存,這一反應(yīng)是濃度依賴性的,不需要胰島素。
740 Y-P is not only internalised in living cells but can also interact with p85 in vivo .740 Y-P (intraperitoneal?injection; 10 mg/kg; 6 weeks) decreases the degree of ROS levels in Aβ(25-32) treated hippocampal tissues and increases the extent of AKT and PI3K phosphorylation in alzheimer’s disease (AD) rat model.