6 -硝基- 7 - 硫氨基苯并[F]喹喔啉-2,3二酮
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- CAS號:
- 479347-86-9
- 英文名:
- 6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt
- 英文別名:
- NSC7169;NSC 7169;NSC-7169;NBQX sodium;3-dione . 2Na;NBQX (sodium salt);FG 9202 disodium salt;NBQX disodium salt - Bio-X ?;6-Nitro-7-sulphamoylbenzo(f)-quinoxaline-2;NBQX disodium salt, AMPA / kainate antagonist
- 中文名:
- 6 -硝基- 7 - 硫氨基苯并[F]喹喔啉-2,3二酮
- 中文別名:
- NBQX二鈉;化合物 NBQX SODIUM;6-硝基-7-氨磺酰苯并[F]喹喔啉-2,3-二酮二鈉鹽;NBQX DISODIUM SALT,AMPA / KAINATE拮抗劑
- CBNumber:
- CB72511387
- 分子式:
- C24H14N8Na2O12S2
- 分子量:
- 716.5239
- MOL File:
- 479347-86-9.mol
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6 -硝基- 7 - 硫氨基苯并[F]喹喔啉-2,3二酮化學(xué)性質(zhì)
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儲存條件:
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-20°C Freezer
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溶解度:
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Soluble in H2O
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形態(tài):
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crystalline solid
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顏色:
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Orange
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水溶解性:
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Soluble to 100 mM in water
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穩(wěn)定性:
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Store in Freezer at -20°C
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6 -硝基- 7 - 硫氨基苯并[F]喹喔啉-2,3二酮性質(zhì)、用途與生產(chǎn)工藝
NBQX disodium (FG9202 disodium) 是高度選擇性，競爭型的 AMPA 受體拮抗劑。NBQX disodium 具有神經(jīng)保護(hù)和抗驚厥活性。
NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex.
NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ.
NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion.
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Animal Model:
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Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)
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Dosage:
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20 mg/kg
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Administration:
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IP; for 3 days
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Result:
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Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.
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6 -硝基- 7 - 硫氨基苯并[F]喹喔啉-2,3二酮
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-15068A | 6 -硝基- 7 - 硫氨基苯并[F]喹喔啉-2,3二酮
NBQX disodium | 479347-86-9 | 5 mg | 1100元 |
| 2026/06/05 | HY-15068A | 6 -硝基- 7 - 硫氨基苯并[F]喹喔啉-2,3二酮
NBQX disodium | 479347-86-9 | 10 mM * 1 mL in DMSO | 1210元 |
6 -硝基- 7 - 硫氨基苯并[F]喹喔啉-2,3二酮
生產(chǎn)廠家
6 -硝基- 7 - 硫氨基苯并[F]喹喔啉-2,3二酮 圖譜信息:
479347-86-9, 6 -硝基- 7 - 硫氨基苯并[F]喹喔啉-2,3二酮 相關(guān)搜索:
- Neurochemicals
- 抑制劑
- NBQX DISODIUM SALT,AMPA / KAINATE拮抗劑
- 化合物 NBQX SODIUM
- NBQX二鈉
- 6-硝基-7-氨磺酰苯并[F]喹喔啉-2,3-二酮二鈉鹽
- 479347-86-9
- NBQX disodium salt - Bio-X ?
- NBQX disodium salt, AMPA / kainate antagonist
- NBQX sodium
- NSC7169
- NSC 7169
- NSC-7169
- FG 9202 disodium salt
- 6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE-2;3-DIONE . 2NA;FG 9202 DISODIUM SALT
- 6-Nitro-7-sulphamoylbenzo(f)-quinoxaline-2
- 3-dione . 2Na
- Benzo[f]quinoxaline-7-sulfonamide,1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-,sodium salt(1:2)
- NBQX (sodium salt)