N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺
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- CAS號(hào):
- 300842-64-2
- 英文名:
- N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
- 英文別名:
- Acc-789;ZK 202650;NVP-ACC-789;ACC-789 (NVP-ACC789);NVP-ACC789, 10 mM in DMSO;ACC-789; ZK-202650; NVP-ACC-789;ACC789;ACC 789;N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine;N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine;1-Phthalazinamine, N-(3-bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-;NVP ACC789,Platelet-derived growth factor receptor,inhibit,ZK 202650,PDGFR,NVPACC789,Inhibitor,ZK-202650,ACC789,NVP-ACC789,VEGFR,ACC 789,NVP-ACC-789,Vascular endothelial growth factor receptor
- 中文名:
- N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺
- 中文別名:
- 化合物NVP-ACC789;化合物NVP-ACC789,10 MM DMSO 溶液;N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺;N-(3-溴-4-甲基苯基)-4-(吡啶-4-基甲基)酞嗪-1-胺
- CBNumber:
- CB72516201
- 分子式:
- C21H17BrN4
- 分子量:
- 405.29
- MOL File:
- 300842-64-2.mol
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N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺化學(xué)性質(zhì)
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沸點(diǎn):
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607.7±55.0 °C(Predicted)
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密度:
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1.441
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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DMSO:13.0(Max Conc. mg/mL);32.08(Max Conc. mM)
DMF:0.5(Max Conc. mg/mL);1.23(Max Conc. mM)
DMF:PBS (pH 7) (1:10):0.09(Max Conc. mg/mL);0.22(Max Conc. mM)
Ethanol:0.2(Max Conc. mg/mL);0.49(Max Conc. mM)-
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形態(tài):
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A crystalline solid
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酸度系數(shù)(pKa):
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5.46±0.10(Predicted)
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顏色:
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Light yellow to yellow
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InChI:
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InChI=1S/C21H17BrN4/c1-14-6-7-16(13-19(14)22)24-21-18-5-3-2-4-17(18)20(25-26-21)12-15-8-10-23-11-9-15/h2-11,13H,12H2,1H3,(H,24,26)
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InChIKey:
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GXWKSXUPEFVUOO-UHFFFAOYSA-N
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SMILES:
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C1(NC2=CC=C(C)C(Br)=C2)C2=C(C=CC=C2)C(CC2C=CN=CC=2)=NN=1
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N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺性質(zhì)、用途與生產(chǎn)工藝
NVP-ACC789 是 人 VEGFR-1，VEGFR-2 (鼠 VEGFR-2)，VEGFR-3 和 PDGFR-β 的抑制劑，IC50 值分別為 0.38，0.02 (0.23)，0.18 和 1.4 μM。
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VEGFR-2
0.02 μM (IC
50
)
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VEGFR-1
0.38 μM (IC
50
)
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mVEGFR-2
0.23 μM (IC
50
)
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VEGFR-3
0.18 μM (IC
50
)
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PDGFR-β
1.4 μM (IC
50
)
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The enzymatic kinase assays demonstrate that NVP-ACC789 is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC
50
s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively. In VEGF-treated cultures, addition of the VEGFR-2 inhibitor NVP-ACC789 reduces BME cell number to baseline levels from 1 μM. Likewise, bFGF-induced BME cell proliferation is reduced markedly by NVP-ACC789 from 1 to 10 μM, without however reaching basal levels. NVP-ACC789 is found to be a potent inhibitor of VEGF-induced HUVE cell proliferation with an IC
50
of 1.6 nM. NVP-ACC789 also completely inhibits VEGF-induced BME and BAE cell invasion and VEGF-C-induced BAE cell invasion. The inhibition is dose-dependent in both cell types with a maximal effect from 1 μM.
NVP-ACC789 which is given in daily oral doses for 6 days blocks VEGF-induced angiogenesis in a dose-dependent manner. NVP-ACC789 also inhibits the response to bFGF to some extent, but the dose-response curve is not linear for NVP-ACC789.
N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2026/06/05 | HY-19624 | N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺
NVP-ACC789 | 300842-64-2 | 1 mg | 200元 |
| 2026/06/05 | HY-19624 | N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺
NVP-ACC789 | 300842-64-2 | 5mg | 310元 |
N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺
生產(chǎn)廠家
N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺 圖譜信息:
300842-64-2, N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺 相關(guān)搜索:
- 抑制劑
- 化合物NVP-ACC789,10 MM DMSO 溶液
- N-(3-溴-4-甲基苯基)-4-(吡啶-4-基甲基)酞嗪-1-胺
- 化合物NVP-ACC789
- N-(3-溴-4-甲基苯基)-4-(4-吡啶甲基)-1-酞嗪胺
- 300842-64-2
- NVP-ACC789, 10 mM in DMSO
- 1-Phthalazinamine, N-(3-bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-
- NVP ACC789,Platelet-derived growth factor receptor,inhibit,ZK 202650,PDGFR,NVPACC789,Inhibitor,ZK-202650,ACC789,NVP-ACC789,VEGFR,ACC 789,NVP-ACC-789,Vascular endothelial growth factor receptor
- N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
- ACC-789; ZK-202650; NVP-ACC-789;ACC789;ACC 789
- ACC-789 (NVP-ACC789)
- NVP-ACC-789
- ZK 202650
- Acc-789
- N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine