氯胍
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- CAS號(hào):
- 500-92-5
- 英文名:
- N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE
- 英文別名:
- PROGUANIL;chlorguanide;bigumal;paludrine;Proquanil;Aids008307;Aids-008307;chloroguanide;ChlorguanideCl;Chlorguanide-D6Cl
- 中文名:
- 氯胍
- 中文別名:
- 氯胍;丙胍雜質(zhì);氯胍-D6;氯胍-D6鹽酸;普羅瓜尼爾-氘6 鹽酸鹽;1-異丙基-5-(4-氯苯基)雙胍;N1-(4-氯苯基)-N5-異丙基雙胍;N-(4-氯苯基)-N'-(異丙基)-雙胍;CHLORGUANIDE (PROGUANIL);rno-miR-653-3p mimicrno-miR-653-3p 模擬物
- CBNumber:
- CB7455742
- 分子式:
- C11H16ClN5
- 分子量:
- 253.73
- MOL File:
- 500-92-5.mol
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氯胍化學(xué)性質(zhì)
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熔點(diǎn):
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129°
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沸點(diǎn):
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399.65°C (rough estimate)
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密度:
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1.2039 (rough estimate)
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折射率:
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1.6110 (estimate)
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儲(chǔ)存條件:
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Store at -20°C, protect from light
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溶解度:
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DMF: 2mg/mL; DMSO: 3mg/mL; DMSO:PBS (pH 7.2) (1:10): 0.09mg/mL; Ethanol: 1mg/mL
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酸度系數(shù)(pKa):
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11.15±0.10(Predicted)
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形態(tài):
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A solid
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顏色:
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White to off-white
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氯胍性質(zhì)、用途與生產(chǎn)工藝
Proguanil (chlorguanide, chloroguanide) 是預(yù)防性抗瘧藥。它能抑制瘧原蟲的二氫葉酸還原酶，阻止嘌呤和嘧啶的合成。
Proguanil per se has only weak antimalarial activity
in vitro
(IC
50
=2.4-19 μM), and its effectiveness depends on the active metabolite Cycloguanil (IC
50
=0.5-2.5 nM). The Cycloguanil is a dihydrofolate reductase (DHFR) inhibitor. The combination of Atovaquone and Proguanil is synergistic
in vitro
. Both drugs also have activity against gametocytes and pre-erythrocytic (hepatic) stages of malaria parasites.
Proguanil acts as a biguanide rather than as its metabolite Cycloguanil (a parasite dihydrofolate reductase [DHFR] inhibitor) to enhance the Atovaquone effect. Proguanil-mediated enhancement is specific for Atovaquone, since the effects of other mitochondrial electron transport inhibitors, such as Myxothiazole and Antimycin, are not altered by inclusion of Proguanil.
5-HT
3
receptor responses are reversibly inhibited by Proguanil, the metabolite 4-chlorophenyl-1-biguanide (CPB) and the active metabolite Cycloguanil (CG), with an IC
50
of 1.81, 1.48 and 4.36 μM, respectively.
Proguanil (p.o.; 2.9 mg/kg body weight; daily for 5 days and 6 weeks respectively) shows mild degenerative changes for five days, while shows severe degenerative changes for six weeks in wistar strain albino rats.
Serum testosterone level is significantly decreased for proguanil treatment rats.
Administration of Malarone (atovaquone and proguanil) to experimentally
B. gibsoni
infected two dogs in chronic stage and three dogs in acute stage results in decrease in parasitemia, and clinical improvements are observed.
生產(chǎn)方法
由硫氯酸鈉與水合肼加成、重排，最后經(jīng)甲醛在乙醇中縮合而制得。
氯胍
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2026/07/06 | S5927 | 氯胍
Proguanil | 500-92-5 | 25mg | 1392.78元 |
| 2026/07/06 | S5927 | 氯胍
Proguanil | 500-92-5 | 1g | 14660.1元 |
500-92-5, 氯胍 相關(guān)搜索:
- 中藥標(biāo)準(zhǔn)品，對(duì)照品
- 抑制劑
- 抗瘧配體
- C11H16ClN5
- 普羅瓜尼爾-氘6 鹽酸鹽
- rno-miR-653-3p mimicrno-miR-653-3p 模擬物
- rno-miR-653-3p mimicrno-miR-653-3p 模擬物
- 1-異丙基-5-(4-氯苯基)雙胍
- CHLORGUANIDE (PROGUANIL)
- 丙胍雜質(zhì)
- 氯胍-D6
- N1-(4-氯苯基)-N5-異丙基雙胍
- N-(4-氯苯基)-N'-(異丙基)-雙胍
- 氯胍-D6鹽酸
- 氯胍
- 500-92-5
- PROGUANIL
- chlorguanide
- Proguanil (Chlorguanide)
- 1-Isopropyl-5-(4-chlorophenyl)biguanide
- Pyridoxine Impurity 50 (Pyridoxine Dipalmitate)
- ProguanilQ: What is
Proguanil Q: What is the CAS Number of
Proguanil Q: What is the storage condition of
Proguanil
- N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE USP/EP/BP
- Chlorguanide (Proguanil)
- Proquanil
- Chlorguanide-d6 HCl
- Imidodicarbonimidic diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-
- Diguanyl (hydrochloride)
- Aids-008307
- Aids008307
- ChlorguanideCl
- Chlorguanide-D6Cl
- Chlorguanide (base and/or unspecified salts)
- 1-(4-chlorophenyl)-5-isopropylbiguanide
- N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE
- paludrine
- chloroguanide
- bigumal
- 1-(p-chlorophenyl)-5-isopropylbiguanide
- 1-(p-chlorophenyl)-5-isopropyl-biguanid