吡考拉唑
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- CAS號:
- 78090-11-6
- 英文名:
- Picoprazole
- 英文別名:
- H-149/94;Picoprazole;1H-Indene-1,3(2H)-dione,5,7-dichloro-;5-methyl-2-[[(3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-Benzimidazole-6-carboxylic acid Methyl ester;6-Methyl-2-[[(3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-5-carboxylic acid methyl ester;1H-Benzimidazole-6-carboxylic acid, 5-methyl-2-[[(3-methyl-2-pyridinyl)methyl]sulfinyl]-, methyl ester
- 中文名:
- 吡考拉唑
- 中文別名:
- 吡考拉唑;化合物 T12471
- CBNumber:
- CB81179493
- 分子式:
- C17H17N3O3S
- 分子量:
- 343.4
- MOL File:
- 78090-11-6.mol
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吡考拉唑化學(xué)性質(zhì)
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儲存條件:
-
Store at -20°C
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溶解度:
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Soluble in DMSO
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吡考拉唑性質(zhì)、用途與生產(chǎn)工藝
Picoprazole 是一種特異性的 H+/K+-ATPase 抑制劑，IC50 為 3.1±0.4 μM。
IC50: 3.1±0.4 μM (H
+
/K
+
-ATPase)
Picoprazole inhibits the H
+
/K
+
-ATPase activity in a concentration-dependent manner. The IC
50
value is 3.1±0.4 μM. Picoprazole is a specific inhibitor of H
+
/K
+
-ATPase and binds to 100-kDa polypeptides of the enzyme, dose dependently inhibited opening of the Cl
-
conductance by Cu
2+
-o-phenanthroline, indicating that the Cl
-
conductance is part of the function of the H
+
/K
+
-ATPase. The inhibitory effect of the three benzimidazole derivatives Timoprazole, Picoprazole, and Omeprazole on histamine and dbcAMP stimulated
14
C-aminopyrine accumulation (H
+
secretion) has been studied in isolated and enriched guinea-pig parietal cells. All compounds tested inhibit H
+
secretion in a concentration dependent manner with IC
50
values of 8.5±1.9 μM for Timoprazole, 3.9±0.7 μM for Picoprazole, and 0.13±0.03 μM for Omeprazole.
吡考拉唑
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
78090-11-6, 吡考拉唑 相關(guān)搜索:
- 抑制劑
- 化合物 T12471
- 吡考拉唑
- 78090-11-6
- 1H-Indene-1,3(2H)-dione,5,7-dichloro-
- 1H-Benzimidazole-6-carboxylic acid, 5-methyl-2-[[(3-methyl-2-pyridinyl)methyl]sulfinyl]-, methyl ester
- Picoprazole
- 5-methyl-2-[[(3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-Benzimidazole-6-carboxylic acid Methyl ester
- H-149/94
- 6-Methyl-2-[[(3-methyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-5-carboxylic acid methyl ester