1-乙氧基羰基環(huán)己-3-烯-4-硼酸頻哪醇酯性質(zhì)、用途與生產(chǎn)工藝

生產(chǎn)方法 

122948-57-6

73183-34-3

1049004-32-1

以4-((三氟甲烷磺酰基)氧基)-3-環(huán)己烯-1-羧酸乙酯（303 mg，1 mmol）和聯(lián)硼酸頻那醇酯（370 mg，1.5 mmol）為原料，加入KOAc（400 mg，4 mmol）和Pd(dppf)Cl2（10 mg，0.05 mmol）于二惡烷（5 mL）中。將反應(yīng)混合物在110℃下加熱16小時(shí)。反應(yīng)完成后，冷卻至室溫，將混合物在EtOAc（10 mL）和飽和NaHCO3溶液（10 mL）之間分配。水相用EtOAc（10 mL × 2）萃取。合并的有機(jī)相用鹽水洗滌，經(jīng)無(wú)水MgSO4干燥，過(guò)濾，濃縮。通過(guò)快速色譜法（25% EtOAc的石油醚溶液）純化，得到4-硼酸頻哪醇酯-3-環(huán)己烯甲酸乙酯（250 mg，收率89%）。LRMS m/z (M + H)+: 281（實(shí)測(cè)值），281（計(jì)算值）。

參考文獻(xiàn)：

[1] Patent: WO2014/81619, 2014, A1. Location in patent: Page/Page column 128

[2] Patent: US2011/251183, 2011, A1. Location in patent: Page/Page column 18

[3] Patent: US2011/263578, 2011, A1. Location in patent: Page/Page column 34

[4] Patent: WO2011/128265, 2011, A1. Location in patent: Page/Page column 34

[5] Patent: US2011/275801, 2011, A1. Location in patent: Page/Page column 49

1-乙氧基羰基環(huán)己-3-烯-4-硼酸頻哪醇酯 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

1-乙氧基羰基環(huán)己-3-烯-4-硼酸頻哪醇酯 生產(chǎn)廠家

1-乙氧基羰基環(huán)己-3-烯-4-硼酸頻哪醇酯 圖譜信息:

1049004-32-1, 1-乙氧基羰基環(huán)己-3-烯-4-硼酸頻哪醇酯 相關(guān)搜索:

• 硼酸頻哪醇酯
• 硼酸酯
• 4-(4,4,5,5-四甲基-1,3,2-二氧雜硼聚糖-2-基)環(huán)己-3-烯-1-羧酸乙酯
• 4-(乙氧羰基)環(huán)己烯-1-頻哪醇硼酸酯
• 4-(乙氧羰基)環(huán)己烯-1-硼酸頻哪醇酯
• 4-硼酸頻哪醇酯-3-環(huán)己烯甲酸乙酯
• ETHYL4-(4,41-乙氧基羰基環(huán)己-3-烯-4-硼酸頻哪醇酯
• 4-(4,4,5,5-四甲基-1,3,2-二噁硼烷-2-基)-3-環(huán)己烯E-1-羧酸乙酯
• 4-(4,4,5,5-四甲基-[1,3,2]二氧雜硼雜環(huán)戊烷-2-基)環(huán)己-3-烯-1-羧基LIC ACID 乙基 酯
• 1-乙氧基羰基環(huán)己-3-烯-4-硼酸頻哪醇酯
• 1049004-32-1
• ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enecarboxylate
• ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-ene-1-carboxylate
• Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-enecarboxylate 97%min
• Bpin-Cyclohexene-COOEt
• ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-ene-1-carboxylateethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-ene-1-carboxylate
• Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cycl...
• 4-(Ethoxycarbonyl)cyclohexene-1-boronic acid, pinacol ester 97%
• Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexene-1-carboxylate
• ethyl 4-(hydroxy((3-hydroxy-2,3-dimethylbutan-2-yl)oxy)boryl)cyclohex-
• 4-(ETHOXY(HYDROXY)BORYL)CYCLOHEX-3-ENECARBOXYLATE PINACOL ESTER
• 4-(4,4,5,5-TetraMethyl-[1,3,2]dioxaborolan-2-yl)-cyclohex-3-enecarboxylic acid ethyl ester
• 4-(Ethoxycarbonyl)cyclohexene-1-boronic acid, pinacol ester
• 3-Cyclohexene-1-carboxylic acid, 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester
• 1-Ethoxycarbonylcyclohex-3-ene-4-boronic acid pinacol ester
• 4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)CYCLOHEX-3-ENE-1-CARBOXYLIC ACID ETHYL ESTER
• Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)
• ethyl 4-(hydroxy((3-hydroxy-2,3-dimethylbutan-2-yl)oxy)boryl)cyclohex-3-enecarboxylate
• 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-Cyclohexene-1-carboxylic acid ethyl ester