6-[4-(叔丁基)苯氧基]吡啶-3-胺
|
|
|
- CAS號:
- 218457-67-1
- 英文名:
- 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
- 英文別名:
- Limantrafin;BUTTPARK 96\12-100;Limantrafin (CB-103);CB-103, 10 mM in DMSO;6-(4-tert-butylphenoxy)-3-pyridinamine;5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE;6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE;6-(4-(tert-butyl)phenoxy)pyridine-3-amine;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%;6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%
- 中文名:
- 6-[4-(叔丁基)苯氧基]吡啶-3-胺
- 中文別名:
- 218457-67-1;CB-103;5-氨基-2-(4-叔丁苯氧基)吡啶;6-[4-(叔丁基)苯氧基]吡啶-3-胺;6-[4-(叔丁基)苯氧基]吡啶-3-胺;CB-103 |CAS 218457-67-1;化合物：CB-103 CAS:218457-67-1;化合物:CB-103 CAS:218457-67-1;6-[4-(叔丁基)苯氧基]吡啶-3-胺,10 MM DMSO 溶液;6-[4-(叔丁基)苯氧基]吡啶-3-胺6-(4-(TERT-BUTYL)PHENOXY)PYRIDIN-3-AMINE;6-[4-(叔丁基)苯氧基]吡啶-3-胺
6-(4-(tert-Butyl)phenoxy)pyridin-3-amine
- CBNumber:
- CB8254830
- 分子式:
- C15H18N2O
- 分子量:
- 242.32
- MOL File:
- 218457-67-1.mol
|
|
|
6-[4-(叔丁基)苯氧基]吡啶-3-胺化學性質
-
熔點:
-
89-90
-
|
-
儲存條件:
-
2-8°C
-
|
-
溶解度:
-
Soluble in DMSO (>30 mg/ml)
-
|
-
形態(tài):
-
solid
-
|
-
顏色:
-
Off-white to pale orange
-
|
-
穩(wěn)定性:
-
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
-
|
-
InChI:
-
1S/C15H18N2O/c1-15(2,3)11-4-7-13(8-5-11)18-14-9-6-12(16)10-17-14/h4-10H,16H2,1-3H3
-
|
-
InChIKey:
-
WHIWGRCYMQLLAO-UHFFFAOYSA-N
-
|
-
SMILES:
-
Nc1cnc(cc1)Oc2ccc(cc2)C(C)(C)C
-
|
-
CAS 數(shù)據(jù)庫:
-
218457-67-1(CAS DataBase Reference)
-
|
6-[4-(叔丁基)苯氧基]吡啶-3-胺性質、用途與生產工藝
CB-103 是一種口服活性的 Notch 轉錄激活復合物的抑制劑。CB-103 可在果蠅和小鼠中產生Notch功能喪失的表型，并抑制人類乳腺癌和白血病異種移植瘤的生長。
CB-103 acts as a pan-NOTCH inhibitor by targeting NOTCH transcriptional activation complex.
CB-103 has shown the ability to block NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines.
CB-103 exhibits anti-tumor efficacy in GSI resistant T-ALL cell lines.
Cell Viability Assay
|
Cell Line:
|
RPMI 8402, KOPTK1, PANC1, nRas driven melanoma cells
|
|
Concentration:
|
10 μM
|
|
Incubation Time:
|
4 days, 6 days
|
|
Result:
|
Caused a significant reduction in their growth potential.
|
CB-103 inhibits NOTCH dependent cellular processes in mice.
CB-103 blocks in vivo growth of PDX models of T-ALL.
CB-103 (25 mg/kg; i.p./p.o.; 2x daily; for 2 weeks) inhibits growth of GSI/Mab resistant triple negative breast cancer.
CB-103 exhibits anti-tumor activity in xenograft models of human T-ALL and mouse mammary tumors.
|
Animal Model:
|
NSG mice, triple negative breast cancer mouse xenograft model
|
|
Dosage:
|
25 mg/kg
|
|
Administration:
|
Oral administration/Intraperitoneal injection; 2x daily; for 2 weeks
|
|
Result:
|
Inhibited growth of GSI/Mab resistant triple negative breast cancer.
|
6-[4-(叔丁基)苯氧基]吡啶-3-胺
上下游產品信息
上游原料
下游產品
| 更新日期 | 產品編號 | 產品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2026/07/06 | S9719 | 6-[4-(叔丁基)苯氧基]吡啶-3-胺
CB-103 | 218457-67-1 | 5mg | 713.16元 |
| 2026/07/06 | S9719 | 6-[4-(叔丁基)苯氧基]吡啶-3-胺
CB-103 | 218457-67-1 | 10mM (1mL in DMSO) | 794.43元 |
6-[4-(叔丁基)苯氧基]吡啶-3-胺
生產廠家
6-[4-(叔丁基)苯氧基]吡啶-3-胺 圖譜信息:
218457-67-1, 6-[4-(叔丁基)苯氧基]吡啶-3-胺 相關搜索:
- 合成有機化合物配體
- 抑制劑
- 合成中間體
- ARYL AMINE
- C15H18N2O
- 化合物：CB-103 CAS:218457-67-1
- 化合物:CB-103 CAS:218457-67-1
- 218457-67-1;CB-103
- CB-103 |CAS 218457-67-1
- 6-[4-(叔丁基)苯氧基]吡啶-3-胺,10 MM DMSO 溶液
- 6-[4-(叔丁基)苯氧基]吡啶-3-胺6-(4-(TERT-BUTYL)PHENOXY)PYRIDIN-3-AMINE
- 6-[4-(叔丁基)苯氧基]吡啶-3-胺
6-(4-(tert-Butyl)phenoxy)pyridin-3-amine
- 6-[4-(叔丁基)苯氧基]吡啶-3-胺
- 5-氨基-2-(4-叔丁苯氧基)吡啶
- 6-[4-(叔丁基)苯氧基]吡啶-3-胺
- 218457-67-1
- Limantrafin
- 6-(4-(tert-butyl)phenoxy)pyridine-3-amine
- Limantrafin (CB-103)
- CB-103, 10 mM in DMSO
- 6-[4-(1,1-Dimethylethyl)phenoxy]-3-pyridinamine
- pathway,CB103,inhibit,Inhibitor,Notch,CB-103,signaling,leukemia,CB 103
- 6-(4-tert-butylphenoxy)-3-pyridinamine
- 3-Pyridinamine, 6-[4-(1,1-dimethylethyl)phenoxy]-
- BUTTPARK 96\12-100
- 6-[4-(TERT-BUTYL)PHENOXY]PYRIDIN-3-AMINE
- 5-AMINO-2-(4-TERT-BUTYLPHENOXY)PYRIDINE
- 6-[4-(tert-Butyl)phenoxy]pyridin-3-amine97%
- 6-[4-(tert-Butyl)phenoxy]pyridin-3-amine 97%