1404231-34-0
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- CAS號:
- 1404231-34-0
- 英文名:
- ON 146040
- 英文別名:
- ON 146040;ON 146040, 10 mM in DMSO;2-((4-(4-Methylpiperazin-1-yl)phenyl)amino)-7-(4-nitrobenzylidene)-5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-one;(7Z)-2-[4-(4-methylpiperazin-1-yl)anilino]-7-[(4-nitrophenyl)methylidene]-5H-pyrimido[4,5-b][1,4]thiazin-6-one;5H-Pyrimido[4,5-b][1,4]thiazin-6(7H)-one, 2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-[(4-nitrophenyl)methylene]-
- 中文名:
- 1404231-34-0
- 中文別名:
- 化合物 T12310;化合物ON 146040;化合物ON 146040,10 MM DMSO 溶液;2-((4-(4-甲基哌嗪-1-基)苯基)氨基)-7-(4-硝基亞芐基)-5H-嘧啶并[4,5-B][1,4]噻嗪-6(7H)-酮
- CBNumber:
- CB82715663
- 分子式:
- C24H23N7O3S
- 分子量:
- 489.55
- MOL File:
- 1404231-34-0.mol
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1404231-34-0化學(xué)性質(zhì)
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儲存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形態(tài):
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Powder
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顏色:
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Brown to reddish brown
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1404231-34-0性質(zhì)、用途與生產(chǎn)工藝
ON 146040 是一種有效的 PI3Kα 和 PI3Kδ 抑制劑，IC50 分別約為 14 和 20 nM。ON 146040 也抑制 Abl1 (IC50<150 nM)。
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PI3Kα
14 nM (IC
50
)
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PI3Kδ
20 nM (IC
50
)
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PI3Kγ
1 μM (IC
50
)
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PI3Kβ
3 μM (IC
50
)
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In biochemical testing, ON 146040 inhibits PI3Kα/ PI3Kδ isoforms (IC
50
≈14 and 20 nM, respectively) without having a major effect on PI3Kβ/ PI3Kγ isoforms (IC
50
≈3 and 1 μM, respectively). ON 146040 is also found to inhibit Abl1 and several mutant versions of this kinase (IC
50
<150 nM), although ON 146040 is not found to be active against the T315I mutant. ON 146040 represents the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways. ON 146040 disrupts the oncogenic activity of both STAT3 and STAT5 by targeting upstream activators, including PI3K α and δ isoforms as well as wild type and mutant BCR-ABL. ON 146040 is highly potent in killing hematologic tumor cells with IC
50
values in the 150 to 1,000 nM range. Following treatment with ON 146040, STAT3 and STAT5 phosphorylation are down-regulated in leukemia and myeloma cells.
1404231-34-0
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
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| 2026/06/05 | HY-12338 | ON 146040 | 1404231-34-0 | 1 mg | 745元 |
| 2026/06/05 | HY-12338 | ON 146040 | 1404231-34-0 | 5 mg | 1850元 |
1404231-34-0, 1404231-34-0 相關(guān)搜索:
- 化學(xué)試劑
- 抑制劑
- C24H23N7O3S
- 化合物ON 146040,10 MM DMSO 溶液
- 2-((4-(4-甲基哌嗪-1-基)苯基)氨基)-7-(4-硝基亞芐基)-5H-嘧啶并[4,5-B][1,4]噻嗪-6(7H)-酮
- 化合物ON 146040
- 化合物 T12310
- 1404231-34-0
- ON 146040, 10 mM in DMSO
- 2-((4-(4-Methylpiperazin-1-yl)phenyl)amino)-7-(4-nitrobenzylidene)-5H-pyrimido[4,5-b][1,4]thiazin-6(7H)-one
- (7Z)-2-[4-(4-methylpiperazin-1-yl)anilino]-7-[(4-nitrophenyl)methylidene]-5H-pyrimido[4,5-b][1,4]thiazin-6-one
- 5H-Pyrimido[4,5-b][1,4]thiazin-6(7H)-one, 2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-[(4-nitrophenyl)methylene]-
- ON 146040