3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸
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- CAS號:
- 161230-88-2
- 英文名:
- (Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE
- 英文別名:
- MDL-105212;MDL 105,519;MDL 105,519 >=98% (HPLC), solid;(Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE;3-[(1E)-2-Carboxy-2-phenylethenyl]-4,6-dichloro-1H-indole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 3-[(1E)-2-carboxy-2-phenylethenyl]-4,6-dichloro-
- 中文名:
- 3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸
- 中文別名:
- 化合物 T16032;化合物 MDL 105519;3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸
- CBNumber:
- CB8317737
- 分子式:
- C18H11Cl2NO4
- 分子量:
- 376.19
- MOL File:
- Mol file
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3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸化學(xué)性質(zhì)
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沸點:
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601.3±55.0 °C(Predicted)
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密度:
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1.594±0.06 g/cm3(Predicted)
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儲存條件:
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Store at -20°C
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溶解度:
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DMSO: 5 mg/mL
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形態(tài):
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solid
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酸度系數(shù)(pKa):
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3.20±0.19(Predicted)
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顏色:
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white
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InChI:
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1S/C18H11Cl2NO4/c19-10-6-13(20)15-12(16(18(24)25)21-14(15)7-10)8-11(17(22)23)9-4-2-1-3-5-9/h1-8,21H,(H,22,23)(H,24,25)/b11-8-
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InChIKey:
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LPWVUDLZUVBQGP-FLIBITNWSA-N
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SMILES:
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OC(=O)C(=C/c1c([nH]c2cc(Cl)cc(Cl)c12)C(O)=O)\c3ccccc3
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3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸性質(zhì)、用途與生產(chǎn)工藝
MDL 105519是有效和選擇性的甘氨酸與 NMDA 受體結(jié)合的拮抗劑。
MDL 105519 is a potent and selective ligand for the glycine recognition site that completely inhibit the binding of [
3
H]glycine to rat brain membranes with a K
i
value of 10.9 nM. MDL 105519 is approximately 10,000-fold selective for the glycine recognition site relative to the other receptor types investigated. MDL 105519 inhibits NMDA-dependent responses, such as elevations of [
3
H]TCP binding in brain membranes, cyclic GMP accumulation in brain slices, and alterations in cytosolic Ca
2+
and Na
+
-Ca
2+
currents in cultured neurons. Inhibition is non-competitive with respect to NMDA and could be nullified with D-serine.
MDL 105519 is an NMDA receptor antagonist
in vivo
. Intravenously administration of MDL 105519 prevents harmaline-stimulated increases in cerebellar cyclic GMP content, providing biochemical evidence of NMDA receptor antagonism
in vivo
. This antagonism is associated with anticonvulsant activity in genetically based, chemically induced, and electrically mediated seizure models. Anxiolytic activity is observed in the rat separation-induced vocalization model, but muscle-relaxant activity is apparent at lower doses. Higher doses impair rotorod performance, but are without effect on mesolimbic dopamine turnover or prepulse inhibition of the startle reflex.
3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS編號 | 包裝 | 價格 |
|---|
| 2026/06/05 | HY-15085 | 3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸
MDL 105519 | 161230-88-2 | 5mg | 1000元 |
| 2026/06/05 | HY-15085 | 3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸
MDL 105519 | 161230-88-2 | 10mM * 1mLin DMSO | 1100元 |
3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸
生產(chǎn)廠家
161230-88-2, 3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸 相關(guān)搜索:
- 抑制劑
- C18H11Cl2NO4
- 化合物 MDL 105519
- 化合物 T16032
- 3-[(1E)-2-羧基-2-苯乙烯基]-4,6-二氯-1H-吲哚-2-羧酸
- 161230-88-2
- 1H-Indole-2-carboxylic acid, 3-[(1E)-2-carboxy-2-phenylethenyl]-4,6-dichloro-
- MDL 105,519 >=98% (HPLC), solid
- (Z)-2-CARBOXY-4,6-DICHLOROINDOLE-3-(2'-PHENYL-2'-CARBOXY)-ENE
- 3-[(1E)-2-Carboxy-2-phenylethenyl]-4,6-dichloro-1H-indole-2-carboxylic acid
- MDL 105,519
- MDL-105212