(Z)-3-(2-(5-(N-(4-氟芐基)氨磺?；?-2-氧代二氫吲哚-3-亞基)肼基)苯甲酸
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- CAS號(hào):
- 1051387-90-6
- 英文名:
- SPI 112
- 英文別名:
- SPI 112;SPI-112;SPI112;SPI-112 ，S0244;SPI-112, 10 mM in DMSO;(Z)-3-(2-(5-(N-(4-Fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid;(z)-3-(2-(5-(n-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazineyl)benzoic acid;SPR,SPI 112,Phosphatase,inhibit,SHP2,Inhibitor,PTP1B,anticancer,PTP,PTPN11,competitive,SPI112,SPI-112;Benzoic acid, 3-[(2Z)-2-[5-[[[(4-fluorophenyl)methyl]amino]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]hydrazinyl]-
- 中文名:
- (Z)-3-(2-(5-(N-(4-氟芐基)氨磺?；?-2-氧代二氫吲哚-3-亞基)肼基)苯甲酸
- 中文別名:
- 化合物SPI 112;SPI-112 ,S0244;1051387-90-6;SPI112;化合物SPI 112,10 MM DMSO 溶液;(Z)-3-(2-(5-(N-(4-氟芐基)氨磺?；?-2-氧代二氫吲哚-3-亞基)肼基)苯甲酸
- CBNumber:
- CB83303342
- 分子式:
- C22H17FN4O5S
- 分子量:
- 468.46
- MOL File:
- 1051387-90-6.mol
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(Z)-3-(2-(5-(N-(4-氟芐基)氨磺酰基)-2-氧代二氫吲哚-3-亞基)肼基)苯甲酸化學(xué)性質(zhì)
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熔點(diǎn):
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>300 °C
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密度:
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1.52±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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4°C, protect from light
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溶解度:
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DMF: 1 mg/ml; DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
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形態(tài):
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A crystalline solid
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酸度系數(shù)(pKa):
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4.15±0.10(Predicted)
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顏色:
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Light yellow to brown
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(Z)-3-(2-(5-(N-(4-氟芐基)氨磺?；?-2-氧代二氫吲哚-3-亞基)肼基)苯甲酸性質(zhì)、用途與生產(chǎn)工藝
SPI-112 是一種有效的，選擇性和競爭性的 SHP2 (PTPN11) 抑制劑，對(duì) SHP2，蛋白酪氨酸磷酸酶 (PTP) 和 PTP1B 的 IC50 分別為 1 μM，18.3 μM 和 14.5 μM。
IC50: 1 μM (SHP2), 18.3 μM (PTP) and 14.5 μM (PTP1B)
SPI-112 has a polar -NO
2
or a negatively charged -COOH group and has no detectable cellular activity, suggesting that SPI-112 is not cell permeable.
In surface plasmon resonance (SPR) binding assay, SPI-112 displays a 1:1 stoichiometric binding kinetics to SHP2 with a kinetic constant K
D
of 1.30 μM. Enzyme kinetic data obtained with SPI-112 are best fitted with the competitive inhibition model (K
i
of 0.8 μM), suggesting that SPI-112 interacts with the catalytic site of SHP2.
(Z)-3-(2-(5-(N-(4-氟芐基)氨磺?；?-2-氧代二氫吲哚-3-亞基)肼基)苯甲酸
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/07/06 | S0244 | (Z)-3-(2-(5-(N-(4-氟芐基)氨磺酰基)-2-氧代二氫吲哚-3-亞基)肼基)苯甲酸
SPI 112 | 1051387-90-6 | 5mg | 4643.73元 |
| 2026/07/06 | S0244 | (Z)-3-(2-(5-(N-(4-氟芐基)氨磺?；?-2-氧代二氫吲哚-3-亞基)肼基)苯甲酸
SPI 112 | 1051387-90-6 | 25mg | 13996.7元 |
(Z)-3-(2-(5-(N-(4-氟芐基)氨磺?；?-2-氧代二氫吲哚-3-亞基)肼基)苯甲酸
生產(chǎn)廠家
(Z)-3-(2-(5-(N-(4-氟芐基)氨磺酰基)-2-氧代二氫吲哚-3-亞基)肼基)苯甲酸 圖譜信息:
1051387-90-6, (Z)-3-(2-(5-(N-(4-氟芐基)氨磺?；?-2-氧代二氫吲哚-3-亞基)肼基)苯甲酸 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- C22H17FN4O5S
- 1051387-90-6;SPI112
- SPI-112 ,S0244
- 化合物SPI 112,10 MM DMSO 溶液
- (Z)-3-(2-(5-(N-(4-氟芐基)氨磺?；?-2-氧代二氫吲哚-3-亞基)肼基)苯甲酸
- 化合物SPI 112
- 1051387-90-6
- (z)-3-(2-(5-(n-(4-fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazineyl)benzoic acid
- SPI-112 ，S0244
- SPI-112, 10 mM in DMSO
- SPR,SPI 112,Phosphatase,inhibit,SHP2,Inhibitor,PTP1B,anticancer,PTP,PTPN11,competitive,SPI112,SPI-112
- (Z)-3-(2-(5-(N-(4-Fluorobenzyl)sulfamoyl)-2-oxoindolin-3-ylidene)hydrazinyl)benzoic acid
- Benzoic acid, 3-[(2Z)-2-[5-[[[(4-fluorophenyl)methyl]amino]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]hydrazinyl]-
- SPI-112;SPI112
- SPI 112