178908-09-3
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- CAS號(hào):
- 178908-09-3
- 英文名:
- UK-240455
- 英文別名:
- UK-240455;UK 240455,UK240455;UK-240455, 10 mM in DMSO;N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(2-hydroxyethyl)methanesulfonamide;Methanesulfonamide, N-(6,7-dichloro-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)-N-(2-hydroxyethyl)-
- 中文名:
- 178908-09-3
- 中文別名:
- 化合物 T13248;化合物UK-240455;化合物UK-240455,10 MM DMSO 溶液
- CBNumber:
- CB84796699
- 分子式:
- C11H11Cl2N3O5S
- 分子量:
- 368.19
- MOL File:
- 178908-09-3.mol
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178908-09-3化學(xué)性質(zhì)
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密度:
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1.686±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系數(shù)(pKa):
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7.96±0.20(Predicted)
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178908-09-3性質(zhì)、用途與生產(chǎn)工藝
UK-240455 是一個(gè)有效且有選擇性的 N-甲基 D-天冬氨酸 (NMDA) 甘氨酸位點(diǎn)上的拮抗劑。
UK-240455 is a potent and selective N-methyl D-aspartate (NMDA) glycine site antagonist. Following i.v. administration of UK-240455 to male rats, UK-240455 has a clearance of 12 mL/min/kg and a volume of distribution of 0.4 L/kg. The plasma concentration of UK-240455 decreases with an apparent half-life of 0.4 h. Analysis of urine (0 to 24 h) for unchanged UK-240455 indicates that 57% of the dose administered is excreted unchanged in the urine. The urinary clearance of UK-240455 in the rat is therefore 7 mL/min/kg. Following oral administration of UK-240455 to male rats, the apparent elimination half-life of UK-240455 from plasma following oral administration is 1.6 h.
178908-09-3
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-19391 | UK-240455 | 178908-09-3 | 1 mg | 3995元 |
178908-09-3, 178908-09-3 相關(guān)搜索:
- 抑制劑
- C11H11Cl2N3O5S
- 化合物UK-240455,10 MM DMSO 溶液
- 化合物UK-240455
- 化合物 T13248
- 178908-09-3
- N-(6,7-Dichloro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)-N-(2-hydroxyethyl)methanesulfonamide
- UK-240455, 10 mM in DMSO
- UK 240455,UK240455
- Methanesulfonamide, N-(6,7-dichloro-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)-N-(2-hydroxyethyl)-
- UK-240455