2,3,6,7-四氫-1H-氮雜卓-1,4-二羧酸 1-叔丁酯 4-乙酯性質(zhì)、用途與生產(chǎn)工藝

生產(chǎn)方法 

912444-88-3

912444-89-4

以化合物（CAS: 912444-88-3）為原料合成2,3,6,7-四氫-1H-氮雜卓-1,4-二羧酸1-叔丁酯4-乙酯的一般步驟：將實(shí)施例42C（0.77 g，2.1 mmol）溶于30 mL苯中，加入DBU（0.9 mL），于60℃反應(yīng)1小時(shí)。反應(yīng)完成后，冷卻反應(yīng)混合物，濃縮，殘余物通過快速柱色譜法（洗脫劑：30% EtOAc的己烷溶液）純化，得到目標(biāo)產(chǎn)物2,3,6,7-四氫-1H-氮雜卓-1,4-二羧酸1-叔丁酯4-乙酯（540 mg，收率95%）。MS（DCI/NH3）m/z 270（M + H）+。

參考文獻(xiàn)：

[1] Patent: US2006/229289, 2006, A1. Location in patent: Page/Page column 22

[2] Angewandte Chemie - International Edition, 2013, vol. 52, # 23, p. 6072 - 6075

[3] Angew. Chem., 2013, vol. 125, # 23, p. 6188 - 6191

[4] Patent: US2018/258065, 2018, A1. Location in patent: Paragraph 0149

[5] Tetrahedron Letters, 2018, vol. 59, # 52, p. 4611 - 4615

2,3,6,7-四氫-1H-氮雜卓-1,4-二羧酸 1-叔丁酯 4-乙酯 上下游產(chǎn)品信息

上游原料

下游產(chǎn)品

2,3,6,7-四氫-1H-氮雜卓-1,4-二羧酸 1-叔丁酯 4-乙酯 生產(chǎn)廠家

2,3,6,7-四氫-1H-氮雜卓-1,4-二羧酸 1-叔丁酯 4-乙酯 圖譜信息:

912444-89-4, 2,3,6,7-四氫-1H-氮雜卓-1,4-二羧酸 1-叔丁酯 4-乙酯 相關(guān)搜索:

• 4-乙基 2,3,6,7-四氫氮雜卓-1,4-二羧酸-(E)-1-叔丁酯
• 2,3,6,7-四氫-1H-氮雜卓-1,4-二羧酸 1-叔丁酯 4-乙酯
• 912444-89-4
• 1H-Azepine-1,4-dicarboxylic acid, 2,3,6,7-tetrahydro-, 1-(1,1-dimethylethyl) 4-ethyl ester
• 2,3,6,7-Tetrahydro-azepine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
• 1-tert-butyl 4-ethyl 2,3,6,7-tetrahydroazepine-1,4-dicarboxylate
• (E)-1-Tert-Butyl 4-Ethyl 2,3,6,7-Tetrahydroazepine-1,4-Dicarboxylate(WX618003)
• 1-O-tert-butyl 4-O-ethyl 2,3,6,7-tetrahydroazepine-1,4-dicarboxylate
• 1-tert-butyl 4-ethyl 2,3-dihydro-1H-azepine-1,4(6H,7H)-dicarboxylate
• (E)-1-tert-Butyl 4-ethyl 2,3,6,7-tetrahydroazepine-1,4-dicarboxylate
• 2,3,6,7-Tetrahydro-1H-azepine-1,4-dicarboxylic acid 1-(tert-butyl) 4-ethyl ester
• 1-tert-butyl 4-ethyl 2,3,6,7-tetrahydro-1H-azepine- 1,4-dicarboxylate