SULINDAC
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- CAS號(hào):
- 49627-27-2
- 英文名:
- SULINDAC SULFIDE
- 英文別名:
- Einecs 256-403-9;SULINDAC SULPHIDE;Sulindac Sulphane;Sulindac Impurity;Z-Sulindac sulphide;Sulindac Impurity C;(Z)-Sulindac sulfide;cis-Sulindac sulfide;Sulindac Impurity N92;Sulinic acid EP impurity C
- 中文名:
- SULINDAC
- 中文別名:
- 舒林酸硫醚;舒林酸硫化物;舒林酸雜質(zhì)N92;舒林酸EP雜質(zhì)C;舒林酸相關(guān)化合物C;化合物 T13037;舒林酸USP相關(guān)化合物C;舒林酸相關(guān)化合物C(USP);舒林酸EP雜質(zhì)C(舒林酸硫化物);舒林酸硫化物,10 MM DMSO 溶液
- CBNumber:
- CB9211728
- 分子式:
- C20H17FO2S
- 分子量:
- 340.41
- MOL File:
- 49627-27-2.mol
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SULINDAC化學(xué)性質(zhì)
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熔點(diǎn):
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189-191°C
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儲(chǔ)存條件:
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-20°C Freezer
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溶解度:
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DMSO: >22 mg/mL
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形態(tài):
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solid
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顏色:
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yellow
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主要應(yīng)用:
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pharmaceutical (small molecule)
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InChI:
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InChI=1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
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InChIKey:
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LFWHFZJPXXOYNR-MFOYZWKCSA-N
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SMILES:
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C1(=C/C2=CC=C(SC)C=C2)/C2=C(C=C(F)C=C2)C(CC(O)=O)=C/1C
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SULINDAC性質(zhì)、用途與生產(chǎn)工藝
Sulindac sulfide 是 γ-secretase 的一個(gè)非競(jìng)爭(zhēng)性抑制劑，其對(duì) γ42-secretase 的 IC50 值為 20.2 μM。
IC50: 20.2 μM (γ
42
-secretase).
Treatment with 100 μM of Sulindac sulfide (SSide) causes cell death presumably by inducing apoptosis, resulting in marked decrease in Aβgeneration as well as in total protein expression. The IC
50
value for Aβ42 secretion of Sulindac sulfide is 30.6±2.8 μM. SSone and naproxen have no effect either on Aβ40 or Aβ42 secretion as well as on Notch cleavage up to 100 μM. It is observed that an inhibition of γ
42
-secretase activity by Sulindac sulfide in a dose-dependent manner. The IC
50
value of SSide for inhibiting γ
42
-secretase activity in vitro is 20.2±2.6 μM. A decrease is found in slope by the increase of the concentration of SSide in the plot of rate against the enzyme concentration, suggesting that Sulindac sulfide is not an irreversible or pseudo-irreversible inhibitor. Moreover, when the dialyzed solubilizedγ-secretase fraction is pretreated with Sulindac sulfide against CHAPSO buffer without Sulindac sulfide, γ-secretase activity is almost totally recovered. From these data, it is strongly suggested that the genuine molecular target of Sulindac sulfide is the γ-secretase complex and that Sulindac sulfide works as a reversible γ-secretase inhibitor.
SULINDAC
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
|---|
| 2026/06/05 | HY-B1786R | SULINDAC
Sulindac sulfide (Standard) | 49627-27-2 | 5 mg | 540元 |
| 2026/06/05 | HY-B1786R | SULINDAC
Sulindac sulfide (Standard) | 49627-27-2 | 10 mg | 810元 |
49627-27-2, SULINDAC 相關(guān)搜索:
- Pharmaceuticals
- Metabolites
- Intermediates & Fine Chemicals
- 標(biāo)準(zhǔn)品
- 配體家族
- 雜質(zhì)對(duì)照品
- 抑制劑
- G Proteins and Cyclic Nucleotides
- G Protein Function
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Reagents
- 舒林酸USP相關(guān)化合物C
- (Z)-2-(5-氟-2-甲基-1-(4-(甲硫基)苯亞甲基)-1H-茚-3-基)乙酸
- 舒林酸硫化物,10 MM DMSO 溶液
- 舒林酸相關(guān)化合物C
- 舒林酸硫化物
- 舒林酸雜質(zhì)N92
- 舒林酸EP雜質(zhì)C(舒林酸硫化物)
- (Z)-5-氟-2-甲基-1-[4-(甲硫苯基)亞甲基]-1H-茚-3-醋酸
- 舒林酸硫醚
- 舒林酸相關(guān)化合物C(USP)
- 舒林酸EP雜質(zhì)C
- 化合物 T13037
- 49627-27-2
- (Z)-5-Fluoro-2-methyl-1-[4-(methylthiophenyl)methylene]-1H-inden-3-acetic acid
- Sulindac Impurity C
- Sulfinyl acid EP impurity C
- Z-Sulindac sulphide
- Sulindac sulfide, 10 mM in DMSO
- Sulindac Sulphane
- 2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfanylphenyl)methylidene]inden-1-yl]acetic acid
- Sulinic acid EP impurity C
- Sulindac Impurity
- Sulindac Impurity N92
- Sulindac EP Impurity C (Sulindac USP Related Compound C, Sulindac Sulfide)
- (Z)-2-{5-fluoro-2-methyl-1-[4-(methylthio)benzylidene]-1H-inden-3-yl}acetic acid
- Sulindac USP Related Compound C
- Sulindac Related Compound C ((Z)-2-{5-fluoro-2-methyl-1-[4-(methylthio)benzylidene]-1H-inden-3-yl}a (1642031)
- 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)-
- Sulindac EP Impurity C (Sulindac Sulfide)
- cis-Sulindac sulfide
- Sulindac Impurity 3（Sulindac EP Impurity C）
- (Z)-5-FLUORO-2-METHYL-1-[P-(METHYLTHIO)BENZYLIDENE]INDENE-3-ACETIC ACID
- SULINDAC SULPHIDE
- Einecs 256-403-9
- 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-, (Z)-
- (Z)-Sulindac sulfide
- 5-Fluoro-2-methyl-1-[(Z)-[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid
- (Z)-5-FLUORO-2-METHYL-1-(4-METHYLTHIOBENZYLIDENE)-1H-INDEN-3-YLACETIC ACID
- (Z)-5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid