226226-39-7
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- CAS號(hào):
- 226226-39-7
- 英文名:
- N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamidehydrochloride
- 英文別名:
- Teijin compound 1;CCR2 antagonist 4;Teijin compound 1 hydrochloride;CCR2 antagonist 4, 10 mM in DMSO;(R)-N-(2-((1-(4-Chlorobenzyl)pyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide;N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxo-ethyl]-3-(trifluoromethyl)benzamide;Benzamide, N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-;N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamidehydrochloride;CCR-2 antagonist 4,CCR2b,CCR,chemokines,chemotaxis,Inhibitor,inhibit,inflammatory,MCP-1,chronic,CCR2 antagonist 4,CC chemokine receptor,Teijin compound1,Teijin compound-1
- 中文名:
- 226226-39-7
- 中文別名:
- 帝人化合物1;化合物 T13114;CCR2 ANTAGONIST 4;化合物CCR2 ANTAGONIST 4;化合物CCR2 ANTAGONIST 4,10 MM DMSO 溶液;(R)-N-(2-((1-(4-氯芐基)吡咯烷-3-基)氨基)-2-代氧乙基)-3-(三氟甲基)苯甲酰胺
- CBNumber:
- CB92518850
- 分子式:
- C21H21ClF3N3O2
- 分子量:
- 439.86
- MOL File:
- 226226-39-7.mol
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226226-39-7化學(xué)性質(zhì)
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沸點(diǎn):
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597.9±50.0 °C(Predicted)
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密度:
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1.37±0.1 g/cm3(Predicted)
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儲(chǔ)存條件:
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Desiccate at +4°C
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溶解度:
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DMSO: ≥20mg/mL
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形態(tài):
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powder
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酸度系數(shù)(pKa):
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12.94±0.46(Predicted)
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顏色:
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white to tan
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226226-39-7性質(zhì)、用途與生產(chǎn)工藝
CCR2 antagonist 4 (Teijin compound 1) 是一種高效、特異的 CCR2 拮抗劑，對(duì) CCR2b 的 IC50 值為 180 nM。CCR2 antagonist 4 對(duì) MCP-1 誘導(dǎo)的趨化作用有較強(qiáng)的抑制作用，其 IC50 為 24 nM。
Ile263 and Thr292 in CCR2 contribute significantly to binding of Teijin compound 1 in CCR2. Residue Glu291 in TM7, a highly conserved residue in many CC chemokine receptors, contributes substantially to binding of the protonated CCR2 antagonist 4, and CCL2. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4.
In ApoE-deficient mice, Vp-TSL targets specifically aortic plaque endothelial VCAM-1 and CCR2 antagonist 4 reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta.
226226-39-7
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS編號(hào) | 包裝 | 價(jià)格 |
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| 2026/06/05 | HY-108323 | 226226-39-7
CCR2 antagonist 4 | 226226-39-7 | 5mg | 990元 |
| 2026/06/05 | HY-108323 | 226226-39-7
CCR2 antagonist 4 | 226226-39-7 | 10mM * 1mLin DMSO | 1089元 |
226226-39-7, 226226-39-7 相關(guān)搜索:
- 抑制劑
- C21H21CIF3O2HCl
- 帝人化合物1
- 化合物CCR2 ANTAGONIST 4,10 MM DMSO 溶液
- (R)-N-(2-((1-(4-氯芐基)吡咯烷-3-基)氨基)-2-代氧乙基)-3-(三氟甲基)苯甲酰胺
- 化合物CCR2 ANTAGONIST 4
- 化合物 T13114
- CCR2 ANTAGONIST 4
- 226226-39-7
- CCR2 antagonist 4, 10 mM in DMSO
- (R)-N-(2-((1-(4-Chlorobenzyl)pyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
- CCR-2 antagonist 4,CCR2b,CCR,chemokines,chemotaxis,Inhibitor,inhibit,inflammatory,MCP-1,chronic,CCR2 antagonist 4,CC chemokine receptor,Teijin compound1,Teijin compound-1
- Benzamide, N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-
- CCR2 antagonist 4
- N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]amino]-2-oxo-ethyl]-3-(trifluoromethyl)benzamide
- Teijin compound 1 hydrochloride
- Teijin compound 1
- N-[2-[[(3R)-1-[(4-chlorophenyl)methyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamidehydrochloride